A Retrospective Study of Double-hit Lymphomas  in Elderly Patients (Aged  & gt;  70 Years): Overall Outcomes

Conclusion Although the numbers are small, elderly patients with DHL can achieve durable EFS and OS. Using the comprehensive geriatric assessment can aid in decision making in the treatment options for elderly patients. Our retrospective analysis, given a small sample size, suggests that intensive treatment regimens can be offered to elderly patients with DHL. Micro-Abstract Double-hit lymphoma can be an aggressive disease that is difficult to treat in the elderly population. We evaluated patients aged > 70 years and their outcomes after treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), R-EPOCH (rituximab, etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin), and other chemotherapy regimens. The results showed the outcomes were dependent on patient performance status and comorbidities. Intensive regimens should be considered for elderly patients who are medically fit.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research