Interfraction variations in organ filling and their impact on dosimetry in CT image based hdr intracavitary brachytherapy

Conclusion: First, this study emphasizes the importance of imaging and planning for every fraction of brachytherapy to quantify the exact doses to the target and OAR s. Second, it is important to follow a uniform bladder protocol for every fraction, and adequate bowel preparation is needed for every fraction to minimize the interfraction variations. Finally, it also opens the realm of an adaptive planning strategy in cervical cancers which are known for rapid tumor regression during radiotherapy.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research