The neurochemistry of agitation in Alzheimer's disease: a systematic review.

CONCLUSIONS: Disruption of the dynamic balance between multiple neurotransmitter systems could impair functional neural networks involved in affective regulation and executive function. Differences in study design and methodology may have contributed to conflicting findings. Future studies that overcome these limitations (e.g. using standardized criteria to define agitation) and employ neuroimaging methods such as MRI/PET to investigate specific neural networks are needed to clarify the role of neurotransmitter alterations in these patients. PMID: 29524596 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29524596?dopt=Abstract

Source: Ageing Research Reviews - March 7, 2018 Category: Genetics & Stem Cells Authors: Liu KY, Stringer AE, Reeves SJ, Howard RJ Tags: Ageing Res Rev Source Type: research