Haematological changes in dogs with prolonged administration of high doses of sulphamethoxazole/trimethoprim

AbstractSulphamethoxazole/trimethoprim (SMX/T) is an antimicrobial agent that has been used for decades against both Gram-positive and Gram-negative bacteria as well as protozoa. It is particularly used as prophylaxis againstPneumocystis carinii pneumonia (PCP) in patients with acquired immune-deficiency syndrome (AIDS). Its use in dogs with associated adverse reactions has necessitated an experimental study that may enhance clinical management of the toxicities. The study aimed to determine the effects of prolonged treatment with high doses of sulphamethoxazole/trimethoprim on the haematological profile of dogs. Dogs were given SMX/T at 30, 60 and 120  mg/kg body weight at 12-h intervals for 21 days. The packed cell volume (PCV), haemoglobin concentration (HbC), red blood cell (RBC) count and total and differential white blood cell (WBC) counts were performed using standard techniques. Data generated was analysed by one-way analysis of variance (ANOVA). Alopecia, epistaxis and skin eruptions were seen at the dose of 120 mg/kg. There were also dose-dependent decreases in the PCV and RBC count. HbC was significantly (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 June 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Meysam Amidfar, Marie Woelfer, Gislaine Z. Réus, João Quevedo, Martin Walter, Yong-Ku KimAbstractThere is accumulating evidence demonstrating that dysfunction of glutamatergic neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in the pathophysiology of major depressive disorder (MDD). Several studies have revealed an altered expression of NMDA receptor subtypes and impaired NMDA receptor-mediated intracellular signaling pathways in brain circuits o...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionIn patients with a skull fracture secondary to assault considering the mechanism of injury being assaulted with a brick significantly excluded, and being stabbed in the head significantly predicted, the intra-operative finding of a dural tear. Considering pre-operative radiology having a depressed skull fracture, pneumocephalus, or intracerebral hematoma were each significant predictive variables of there being an intra-operative dural tear.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Abstract Background: Chronic migraine with medication overuse headache (CM-MOH) is the most common type of chronic migraine, and it increases risk of stroke and white matter lesions. These pathologic changes could induce cognitive decline. However, the alteration of cognitive function in CM-MOH patients is not established. Therefore, we took this study to reveal the cognitive performances in CM-MOH. Methods: This cross-sectional study was conducted between December 2015 and January 2017. Patients were divided into CM-MOH, CMwoMOH (chronic migraine without medication overuse), and MO (migraine without aura) gr...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
This study aimed to investigate if the seleno-organic compound 1-methyl-3-(phenylselanyl)-1H-indole (MFSeI) reverses the depression- and anxiogenic-like behaviour, cognitive impairment and oxidative stress induced by the intra-cerebroventricular injection of streptozotocin (STZ; 0.2 mg/4 μl/per mouse) in Swiss male mice. Twenty-four hours after the STZ injection, mice were treated with MFSeI (10 mg/kg, intra-gastrically), or vehicle solution, once daily for seven days. The behavioural tests were performed 30 min after the final MFSeI administration, followed by euthanasia and collection of the cerebral cortex an...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Authors: Chen YY, Huang LY, Liao WL, Chou P Abstract Purpose: To investigate the association between central serous chorioretinopathy (CSC) and the risk of developing depression. The risk factors associated with depression in CSC patients were also assessed. Methods: A population-based retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted from the beginning of 2001 through the end of 2013. CSC patients and age- and gender-matched (1 : 4 matched) control subjects without CSC were enrolled in the study. Kaplan-Meier curves were generated to compare the...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
CONCLUSION: The PEI showed fair content validity, construct validity and internal consistency. However, the scale needs further development to improve measurement of change. PMID: 31198975 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
CONCLUSION: Normocapnic hyperpnoea training may reduce the incidence of respiratory symptoms, improve pulmonary function and quality of life, and reduce depression in patients with chronic spinal cord injury, regardless of their neurological level of injury, even at more than 24 months after injury. PMID: 31198974 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
PURPOSE: We use data from a community sample, the Columbia County Longitudinal Study, which followed participants from childhood through adulthood, to examine the longitudinal relations between mental health (serious anxiety and serious depression) and off...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Around 8% of bipolar disorder (BD) patients die by suicide every year, accounting for the highest rate among the psychiatric population. Suicidal behavior (SB) is mediated by an intertwining system of extrinsic and intrinsic factors. Childhood ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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