NLM Resources: LactMed for Nurses

LactMed, a free database about drugs and lactation, is produced by the National Library of Medicine. It is available via the website, https://toxnet.nlm.nih.gov/newtoxnet/lactmed.htm, or as a mobile app. LactMed provides information on many of the drugs and chemical to which nursing mothers may be exposed, including dietary supplements. The information contained in LactMed includes: Summary statement about use of the drug during lactation; Measurement of levels of the drug in breastmilk; Effects in breastfed infants; Effects on lactation; Alternate drugs to consider. References to research studies are also included with each entry (with links to the citations in PubMed), and all of the data in LactMed is a result of peer-reviewed literature. The database is updated monthly to reflect current research. Records may be downloaded and/or printed for yourself or for your patients. Summary of Use During Lactation: This part of the record offers guidance on the use of the drug or substance during breastfeeding. It summarizes the important points which are provided in the record. If there are conflicting recommendations by experts, the summary mentions all and gives citations to the research. Drug Levels, Maternal and Infant: This section summarizes studies that have measured drug concentrations in breastmilk, and serum or urine concentration in infants. Effects in Infants: Known side effects from the published literature are included here, using an adverse drug reaction assessment m...
Source: Dragonfly - Category: Databases & Libraries Authors: Tags: News from NLM Training & Education Source Type: news

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Publication date: Available online 15 December 2018Source: The American Journal of SurgeryAuthor(s): Anne E. van Heesewijk, Rosa G.M. Lammerts, Jan-Willem Haveman, Mark Meerdink, Barbara L. van Leeuwen, Robert A. PolAbstractBackgroundCholecystectomy is considered the standard treatment for acute cholecystitis and symptomatic gallstones. An increasing number of frail elderly patients are being referred for this surgical treatment. A better understanding of surgical outcome in the elderly is needed to improve quality of care.MethodsA retrospective analysis of 565 patients who underwent cholecystectomy was performed. Focus of...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
In this study, the antineuroinflammatory effect of simvastatin was examined in lipopolysaccharide (LPS)-activated rat C6 glioma cells. The cell proliferation and cytotoxic effect of LPS and simvastatin on C6 glioma cells was evaluated by (MTT) assay. Neuroinflammation was induced in differentiated cell lines by treatment with 3.125 μg/mL of LPS for 12 h. Upon induction, the cell lines were treated with different concentrations (3.125, 6.25, 12.5, 25, 50, 100 μM) of simvastatin and incubated in a humidified CO2 incubator for 24 to 48 h. The optimum concentrations of LPS and simvastatin were found to be 3.125 μg/mL ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Park SM, Kim SW, Jung EH, Ko HL, Im CK, Lee JR, Byun SH, Ku SK, Kim SC, Park CA, Kim KJ, Cho IJ Abstract Sipjeondaebo-tang (SDT) is used frequently as a herbal prescription to treat deficiency syndromes in traditional Korean medicine. We investigated the hepatoprotective effects of SDT against oxidative stress and attempted to clarify the underlying molecular mechanisms. SDT pretreatment reduced arachidonic acid (AA) plus iron-mediated cytotoxicity in a concentration-dependent manner and prevented changes in apoptosis-related protein expression. In addition, SDT pretreatment significantly reduced glutathio...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Li Z, Lan D, Zhang H, Zhang H, Chen X, Sun J Abstract The aim of this work is to investigate the effect of electroacupuncture (EA) on insulin sensitivity in high-fat diet (HFD) induced insulin resistance (IR) rats and to evaluate expression of AMPK/ACC signaling components. Thirty-two male Sprague-Dawley rats were randomized into control group, HFD group, HFD+Pi (oral gavage of pioglitazone) group, and HFD+EA group. Acupuncture was subcutaneously applied to Zusanli (ST40) and Sanyinjiao (SP6). For Zusanli (ST40) and Sanyinjiao (SP6), needles were connected to an electroacupuncture (EA) apparatus. Fasting p...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study describes the main chemical compounds present in extracts of O. fieldingiana and evaluates their biological potential by investigating antifungal, antioxidant, and anticholinesterase activities. The action mechanism of main antifungal compound was investigated by molecular docking using the enzyme sterol 14-α demethylase, CYP51, required for ergosterol biosynthesis. The seeds and leaves were extracted with ethanol in a Soxhlet apparatus and by maceration, respectively. Both extracts were subjected to silica gel column chromatography for isolation of main constituents, followed by purification in sephadex. ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In this study, we investigated the mechanism of action of dandelion chloroform extract (DCE) on glucose uptake in L6 cells. The glucose consumption of L6 cell culture supernatant was measured by a glucose uptake assay kit, and the dynamic changes of intracellular GLUT4 and calcium (Ca2+) levels were monitored by laser scanning confocal microscopy in L6 cell lines stably expressing IRAP-mOrange. The GLUT4 fusion with the plasma membrane (PM) was traced via myc-GLUT4-mOrange. GLUT4 expression and AMP-activated protein kinase (AMPK), protein kinase B (PKB/Akt), protein kinase C (PKC), and phosphorylation levels were determine...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionAs conventional therapies may not be sufficiently effective, women's needs should be closely examined, and individual treatment options should be discussed and initiated by clinicians to provide the best comprehensive treatment possible for endometriosis.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
CONCLUSION: The results indicate that FTD/TPI may represent a cost-effective treatment option compared with other alternative therapies as a third-line treatment of metastatic colorectal cancer in Greece. PMID: 30547679 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
Meditation can influence many aspects of health and well-being. Now, new evidence suggests that it also affects how the brain learns from past experience.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Complementary Medicine / Alternative Medicine Source Type: news
We describe the safe and effective use of epoprostenol sodium as an alternative therapy before heparin exposure for a pediatric patient with subacute heparin-induced thrombocytopenia and a ventricular assist device undergoing heart transplant.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
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