Haematopoiesis: “living in the shadow” of stem cell differentiation.

Haematopoiesis: “living in the shadow” of stem cell differentiation. J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1):1-6 Authors: Jankowski M, Dyszkiewicz-Konwińska M, Magas M, Skorupski M, Gorecki G, Bukowska D, Antosik P, Jeseta M, Bruska M, Nowicki M, Zabel M, Kempisty B Abstract Haematopoiesis is one of the most well understood stem-cell associated processes. It is a process in which pluripotent hematopoietic stem cells (HSCs) self-proliferate and differentiate into all types of blood cells. The process takes place in marrow of the flat bones in adults, however its location changes several times through embryonic and foetal development. Given the broad range of blood cells and the major differences in their build and function, together with the fact that their numbers need to be maintained within relatively narrow margins in order to maintain homeostasis despite changing environmental conditions, makes the whole process of haematopoiesis highly regulated and depending on a variety of growth factors. When influenced by those, HSCs undergo several irreversible steps, with every next one committing them to an even more specialised fate, ending with all the specific types of mostly short-lived blood cells, that are unable to proliferate on their own and need constant replenishment from the HSC pool. Because the process of haematopoiesis is the only source of all the members of the group of cells performing a range of highly import...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research