Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder.

CONCLUSIONS: This study is the first to examine the anatomical specificity of thalamo-cortical connectivity disturbances in MDD. Subjects with MDD demonstrated altered thalamo-cortical connectivity characterized by a complex pattern of region-dependent hypo- or hyperconnectivity. We therefore speculate that selectively modulating the connectivity of thalamo-cortical circuitry may be a potential novel therapeutic mechanism for MDD. PMID: 29493113 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29493113?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 28, 2018 Category: Neuroscience Authors: Kong QM, Qiao H, Liu CZ, Zhang P, Li K, Wang L, Li JT, Su Y, Li KQ, Yan CG, Mitchell PB, Si TM Tags: CNS Neurosci Ther Source Type: research