The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.

Conclusions: Loss of RB confers increased radiosensitivity in prostate cancer. This hypersensitization was mediated by alterations in apoptotic signaling. Combined, these not only provide insight into the molecular consequence of RB loss, but also credential RB status as a putative biomarker for predicting response to radiation therapy.
PMID: 25165096 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - August 27, 2014 Category: Cancer & Oncology Authors: Thangavel C, Boopathi E, Ciment S, Liu Y, O'Neill R, Sharma A, McMahon SB, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker AP, Knudsen KE, Den R Tags: Clin Cancer Res Source Type: research