Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

This study investigated the association of theSOD2polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321;p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285;p=0.0090, respectively). These results suggest that theSOD2polymorphism associated with low SOD activity could be involved in SCA physiopathology.  
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research