Concurrent Alzheimer's pathology in patients with clinical normal pressure hydrocephalus.

CONCLUSIONS: There is a high prevalence of AD in patients who are shunted for a clinical diagnosis of NPH. The presenting symptoms of NPH and AD may be very similar and the significant difference in histopathology is what separates the two disease processes. There may be temporary relief with restoring cerebrospinal fluid flow but the presence of underlying neurodegenerative changes more directly correlates with long-term outcomes. There may also be a direct correlation between altered CSF dynamics in both the metabolic clearance and the development of dementia. PMID: 29444559 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research