Effect of Intensive Blood Pressure Control in Patients with Type 2 Diabetes Mellitus Over 9 Years of Follow ‐Up: A Subgroup Analysis of High‐Risk ACCORDION Trial Participants
Abstract Although guidelines recommend strict blood pressure (BP) control in patients with type 2 diabetes mellitus (T2DM) and elevated cardiovascular risk, the long‐term effects of this approach are unknown. We investigated the effect of intensive BP control on clinical outcomes in patients with T2DM over 9 years of follow‐up. We included ACCORD BP participants in the standard glucose control arm who had established cardiovascular disease, chronic kidney disease, age ≥75 years or 10‐year coronary heart risk ≥15%. Participants were randomized to either intensive (systolic BP
Authors: Xie Z, Chang C, Huang G, Zhou Z Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may change the expression of genes through epigenetic mechanisms, thus inducing individuals with susceptible genes to develop T1D; however, the underlying mechanisms remain ...
I'm stuck. Do I use the adversity essay to explain bad grades? I would prefer not to, because I cannot discuss the true circumstances of my bad grades 10 years ago (drinking problem), only discuss my growth in vague language, so it feels stupid. Current list of topics: "Overcame myself and my terrible grades" I was bullied as a kid for being fat, became obese as an adult, dx prediabetic, made drastic changes, attained healthy body weight, it was really hard. I can relate to my... Adversity prompt feedback - overcoming obesity vs bad grades vs sports injury
CONCLUSION: As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction. PMID: 32444531 [PubMed - as supplied by publisher]
Conditions: Stroke; Sleep-disordered Breathing; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Sleep Apnea, Central; Fragmentation, Sleep Intervention: Device: Treatment according to standard care recommandation Sponsor: University Hospital, Grenoble Not yet recruiting
Conditions: Stroke; Activities of Daily Living Interventions: Behavioral: Approach-Instrumental Activities of Daily Living; Behavioral: Home rehabilitation Sponsor: National Taipei University of Nursing and Health Sciences Recruiting
Conditions: Overweight or Obesity; Body Weight Interventions: Other: Dairy-based commercially available food products; Other: Restrictive Eating Sponsors: University of Toronto; Mount Saint Vincent University Not yet recruiting
Condition: Foot Ulcer, Diabetic Intervention: Other: No intervention Sponsors: Podimetrics, Inc.; American Association of Diabetes Educators Enrolling by invitation
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Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Chronic kidney disease (CKD) affects a substantial minority of people with type 2 diabetes (T2D). Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed Stage 3 or worse disease (estimated glomerular filtration rate [eGFR]