Development of an inflammation imaging tracer, 111 In-DOTA-DAPTA, targeting chemokine receptor CCR5 and preliminary evaluation in an ApoE −/− atherosclerosis mouse model

Conclusion111In-DOTA-DAPTA, specifically targeting chemokine receptor CCR5, is a potential SPECT agent for imaging inflammation in atherosclerosis.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

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Consecutive milestones in hip arthroplasty design and surgical technique have contributed to the successful and cost-effective intervention this procedure has become today in maintaining mobility and quality of life in patients with osteoarthritis, fracture, or other hip conditions. With the increasing prevalence of hip joint replacements, the need for improved diagnostic imaging tools to guide revision surgery has risen in parallel. Over the last few years, promising data have emerged on the potential role of bone SPECT/CT imaging in the assessment of patients with recurrent pain after arthroplasty.
Source: Seminars in Nuclear Medicine - Category: Nuclear Medicine Authors: Source Type: research
In this review we summarize the current evidence and experience regarding the performance of SPECT/CT in the evaluation of patients with postoperative painful wrist or hand. There is a wide range of operative wrist and hand interventions due to congenital, traumatic, degenerative, or inflammatory diseases. A significant number of patients suffer from pain after operative procedures. Several imaging modalities have been used to evaluate the reason for painful postoperative wrists like standard conventional x-rays, ultrasound, CT, MRI, or bone scintigraphy.
Source: Seminars in Nuclear Medicine - Category: Nuclear Medicine Authors: Source Type: research
AbstractBackground The applicability of ultra-low-dose computed tomography (CT) for attenuation correction (AC) of single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI) remains elusive.Methods and resultsOne-hundred patients underwent one-day99mTc-tetrofosmin stress-rest MPI and non-contrast enhanced cardiac CT with 120, 80, and 70  kilovolt peak (kVp) tube voltage and tube current of 200 milliamperes for creation of AC maps. Normalized percent myocardial uptake from SPECT-MPI using 80 kVp scans for AC showed excellent correlation vs AC from 120 kVp scans for stress [intr...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
ConclusionThe REFINE SPECT registry will provide a resource for collaborative projects related to the latest generation SPECT-MPI. It will aid in the development of new artificial intelligence tools for automated diagnosis and prediction of prognostic outcomes.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
This study is adopting this recent improvement in GATE to study arms effect in SPECT imaging with the consideration of four scenarios; normal heart perfusion imaging with and without arms positioned next to the patient and two of the same scenarios with a perfusion myocardial defected. The results showed that perfusion defect could be observed with arms next to the patient. For image reconstruction, both filtered backprojection (FBP) and iterative technique - maximum likelihood expectation maximization (MLEM) were used. The MLEM was performed to analyse the four different patient senarios. The difference in counts between ...
Source: Results in Physics - Category: Physics Source Type: research
Publication date: 1 August 2018 Source:Journal of Organometallic Chemistry, Volume 868 Author(s): Xiaojiang Duan, Qing Ruan, Qianqian Gan, Xiaoqing Song, Si'an Fang, Xuran Zhang, Junbo Zhang A series of novel thymidine dithiocarbamate derivatives (DTC-TdR) were successfully synthesized and then radiolabelled using [99mTc(CO)3]+ core with high yields. The chemical characterizations of 99mTc(CO)3-labelled dithiocarbamate derivatives have been carried out by preparing their corresponding rhenium complexes. The radiotracers were stable in vitro, and the partition coefficient results indicated that they were lipophilic. T...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
CONCLUSION: Pretreatment with KRG before RI therapy could be useful to protect against RI induced salivary dysfunction. PMID: 29905085 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
In this study, PMX was combined with the currently best performing radiofolate ([177Lu]cm13), which is outfitted with an albumin-binding entity. Biodistribution studies were carried out in mice bearing KB or IGROV-1 tumor xenografts, both FR-positive tumor types. SPECT/CT was performed with control mice injected with [177Lu]folate only and with mice that received PMX in addition. Control mice showed high uptake of radioactivity in KB and IGROV-1 tumor xenografts, but retention in the kidneys was also high, resulting in tumor-to-kidney ratios of ~0.85 (4 h p.i.) and ~0.60 (24 h p.i.) or ~1.17 (4 h p.i.) and ~1.11 (24 h p.i....
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Background Myocardial perfusion single-photon emission computed tomography (SPECT) with thallium (Tl)-201 is an established modality for evaluating myocardial ischemia. We assessed the effects of atrial fibrillation (AF) on the myocardial washout rate (WR) of Tl-201 on myocardial perfusion SPECT. Patients and methods A total of 231 patients with no evidence of myocardial ischemia were enrolled retrospectively in this study. Patients were divided into two groups on the basis of the ECG at the time of myocardial perfusion SPECT. The mean myocardial WR of Tl-201 was calculated from the stress and the redistribution Bull&...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conclusion It is necessary that Quantitative SPECT be acquired at 50 s or more per view per detection, reconstructed using a three-dimensional ordered subset expectation maximization with SC+/AC+, the SI product is 150 times, and the Gaussian Filter is 8–12 mm. This suggested that the quantitative analysis would be carried out with good reproducibility.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
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