Development of an inflammation imaging tracer, 111 In-DOTA-DAPTA, targeting chemokine receptor CCR5 and preliminary evaluation in an ApoE −/− atherosclerosis mouse model

Conclusion111In-DOTA-DAPTA, specifically targeting chemokine receptor CCR5, is a potential SPECT agent for imaging inflammation in atherosclerosis.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

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Authors: Sarikaya I, Sarikaya A Abstract Objective: Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) has limited value in early breast cancer. Sentinel lymph node (SLN) biopsy is the current procedure of choice to search for small metastatic deposits in the axillary lymph nodes in early breast cancer. In this retrospective study, we re-evaluated 18F-FDG PET/CT images after locating SLN(s) on PET/CT with the help of SLN single photon emission computed tomography/computed tomography (SPECT/CT) images and assessed 18F-FDG uptake particularly in the SLN(s). Our goal was...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Publication date: Available online 10 November 2018Source: Cirugía Española (English Edition)Author(s): Dennis César Lévano-Linares, Jaime Ruiz-Tovar, Alejandro García Muñoz-Najar, Verónica Familiar, Manuel Durán Poveda
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 8 November 2018Source: International Review of NeurobiologyAuthor(s): Pierre-Alexandre Bourgouin, Shady Rahayel, Malo Gaubert, Dario Arnaldi, Michele Hu, Anna Heidbreder, David Rémillard-Pelchat, Michele Terzaghi, Jean-François GagnonAbstractIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by the loss of muscle atonia and the presence of undesirable motor manifestations during rapid eye movement sleep. Research findings have shown that iRBD is a prodromal stage of synucleinopathies such as Parkinson's disease, dementia with Lewy bodi...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Much of what we think we know about cannabis may soon change as a result of new research that uncovers some surprising facts. Indeed, the topic, which can be emotionally charged, is the focus of intense scientific study. Is cannabis good for you? Is it addictive? What long-term harms can use cause? The answers to these questions are multi-layered and not always clear-cut, which is why cannabis research continues with even more urgency. FACTS ON CANNABIS ADDICTION AND DEPENDENCE Current estimates are that one in 10 cannabis users will develop cannabis addiction or dependence. The potency of the delta-9-tetrahydrocannabinol ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Habits Healthy Living Memory and Perception Miscellaneous Drugs Neuroscience Substance Abuse Source Type: news
Publication date: Available online 23 October 2018Source: Brain StimulationAuthor(s): Silvia Casarotto, Francesco Turco, Angela Comanducci, Alessio Perretti, Giorgio Marotta, Gianni Pezzoli, Mario Rosanova, Ioannis U. IsaiasAbstractBackgroundCortical dysfunctioning significantly contributes to the pathogenesis of motor symptoms in Parkinson's disease (PD).ObjectiveWe aimed at testing whether an acute levodopa administration has measurable and specific cortical effects possibly related to striatal dopaminergic deficit.MethodsIn thirteen PD patients, we measured the electroencephalographic responses to transcranial magnetic ...
Source: Brain Stimulation - Category: Neurology Source Type: research
Researchers from the U.S. and China are developing a SPECT tracer that could...Read more on AuntMinnie.comRelated Reading: Novel PET tracer may improve NSCLC patient management FDG-PET/CT could improve treatment for NSCLC patients Study questions value of CT scans after NCSLC surgery SNMMI: FDG-PET can monitor immunotherapy for NSCLC
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This study aimed to determine the prevalence of excessive lateral pressure syndrome (ELPS) in potential candidates for high tibial osteotomy (HTO) using single-photon emission computed tomography –computed tomography (SPECT–CT). We also sought to identify risk factors related to the presence of ELPS.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Publication date: 2018Source: International Review of Neurobiology, Volume 142Author(s): Joachim Brumberg, Ioannis U. IsaiasAbstractAtypical parkinsonism is the second most common diagnosis for patients with hypokinetic movement disorders. Beside common parkinsonian symptoms (i.e. bradykinesia and muscular rigidity) patients may also present a variety of additional motor and non-motor symptoms, such as oculomotor abnormalities, postural instability, ataxia, limb apraxia, autonomic dysfunctions, etc. Clinical heterogeneity and gradual manifestation during the disease course often hamper the diagnosis and adequate treatment....
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: 2018Source: International Review of Neurobiology, Volume 142Author(s): Zheyu Xu, Javier Arbizu, Nicola PaveseAbstractMultiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal Degeneration are three neurodegenerative disorders characterized by parkinsonism along with involvement of other brain cortical and subcortical regions. The ante mortem diagnosis of these disorders is extremely challenging with up to a quarter of these patients being misdiagnosed, particularly in the early stages of disease.While highly specific and sensitive imaging biomarkers of individual atypical parkinsonisms hav...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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