Microscopic peritoneal carcinomatosis in gastric cancer: Prevalence, prognosis and predictive factors.

Microscopic peritoneal carcinomatosis in gastric cancer: Prevalence, prognosis and predictive factors. Oncol Lett. 2018 Jan;15(1):710-716 Authors: Pasqual EM, Bertozzi S, Londero AP, Brandolin D, Mariuzzi L, De Pellegrin A, Bacchetti S, Zoratti L, Petri R, Della Bianca C, Snidero D, Terrosu G, Uzzau A, Risaliti A, Di Loreto C, Pizzolitto S, Zilli M, de Manzoni G Abstract Peritoneal carcinomatosis (PC) is typically identified in advanced stage gastric cancer and is frequently considered to be an incurable disease. Along with macroscopic PC, microscopic PC may be diagnosed through pathological examination of tissue specimens and is not detectable during surgical intervention. The present study aimed to analyse the prevalence, prognostic value and predictive factors for microscopic PC. In the present retrospective study, data from patients with epithelial gastric cancer that were treated with curative intent surgery were examined. Patients with macroscopic PC were excluded. Additionally, the study population was divided into two groups based on the presence or absence of microscopic PC. The prevalence of microscopic PC was 5.5%. Microscopic PC exhibited a significant negative effect on overall survival. In addition, multivariate analyses revealed that the significant predictive factors for the presence of microscopic PC were adenocarcinoma of a diffuse type, lymphatic and vascular invasion, cancer location at the site of previous gastri...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research