Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in A β1-42-Treated Rats.

In this study, we investigated the role of estrogen receptors (ERs) in silibinin's neuroprotective effect on Aβ1-42-injected rats. Results of Morris water maze and novel object-recognition tests demonstrated that silibinin significantly attenuated Aβ1-42-induced memory impairment. Silibinin attenuated ERs and PI3K-Akt pathways, as well as modulated mitogen-activated protein kinases in the hippocampus of Aβ1-42-injected rats. Taken together, silibinin is a potential candidate in the treatment of Alzheimer's disease.
PMID: 29397533 [PubMed - as supplied by publisher]

Source: Neurochemical Research - February 3, 2018 Category: Neuroscience Authors: Song X, Liu B, Cui L, Zhou B, Liu L, Liu W, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Ikejima T Tags: Neurochem Res Source Type: research