Cerebrospinal fluid biomarkers of Alzheimer ’s disease are associated with carotid plaque score and hemodynamics in intra- and extra-cranial arteries on ultrasonography

Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Minoru Kouzuki, Masaya Nagano, Tetsuya Suzuki, Yuto Katsumata, Syouta Nakamura, Ayumi Takamura, Katsuya Urakami Carotid plaque score (PS) and hemodynamic abnormalities in intra- and extra-cranial arteries are related to Alzheimer’s disease (AD) progression. As these parameters are measured conveniently and non-invasively by ultrasonography, we examined their association with cerebral spinal fluid (CSF) AD biomarkers amyloid β (Aβ) and phosphorylated tau (p-tau). Carotid PS, mean flow velocity (MFV) in multiple intra- and extra-cranial arteries, CSF Aβ42 and p-tau, neurocognitive function (assessed by the Mini-Mental State Examination and Alzheimer’s Disease Assessment Scale-cognitive subscale, Japanese version), and blood lipids (total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride) were measured in AD patients (n = 42), mild cognitive impairment patients (n = 20), and cognitively normal controls (n = 18). The results were also compared among groups defined by PS range. After adjusting for blood lipids as covariates, Aβ42 was higher in the PS = 1.1−2.0 mm group than in the higher PS groups (2.1−3.0, 3.1−5.0, 5.1−7.0, and >7.0 mm). However, subjects with very low PS (<1.1 mm) also had a low mean CSF Aβ42. Alternatively, CSF p-tau181 did not differ between PS groups. In multiple regression analysis, Aβ42 was n...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research