Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters.

CONCLUSION: These apparently conflicting results may reflect LP-211 effects on visual vs spatial memory (D/L apparatus has more pronounced hippocampal components than BWB). However, further experiments are needed to analyze more in depth the mechanisms involved.
PMID: 29392842 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - February 1, 2018 Category: Neuroscience Authors: Carbone C, Adinolfi A, Cinque S, Lacivita E, Alleva E, Leopoldo M, Adriani W Tags: CNS Neurosci Ther Source Type: research