Gene therapy: Reprogramming α -cells reverses diabetes

Nature Reviews Drug Discovery 17, 93 (2018). doi:10.1038/nrd.2018.7 Author: Sarah Crunkhorn Autoimmune destruction of insulin (INS)-producing pancreatic β-cells, resulting in persistent hyperglycaemia, underlies the pathogenesis of type 1 diabetes. Preserving and restoring functional β-cell mass is therefore a fundamental objective of diabetes therapy. Writing in Cell Stem Cell, Gittes and colleagues report the successful conversion
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research