A novel expandable porous composite based on acetalized polyvinyl alcohol and calcium sulfate used for injectable bone repair materials

In this study, a novel expandable bone cement was prepared with acetalized polyvinyl alchol porous material (APVA-PM) and CSH. By controlling the content of APAV-PM, composite cements with different structures and morphology were obtained and investigated by using SEM, FT-IR, XRD. The physical properties including setting time, porosity and expansion ratio were studied. CSH/APVA-PM bone cement could produce volume expansion in the setting process and form a porous structure after curing. The setting time decreased with the increase of the volume fraction of APVA-PM. APVA-PM improved the toughness of calcium sulfate cement, thus overcoming the present mechanical limitations. In vitro experiments demonstrated the CSH/APVA-PM bone cement did not show cytotoxicity and the porous structure allowed the rat bone marrow stem cells (BMSCs) to grow into the pores. Therefore, CSH/APVA-PM bone cement appeared to be useful for bone tissue engineering and can potentially serve as a new filling material. Graphical abstract
Source: Composites Science and Technology - Category: Science Source Type: research