Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers

Conclusion: Myeloid Notch1 deficiency activates the ras homolog gene family member A/ROCK pathway and exacerbates hepatocellular injury by inhibiting transcriptional repressor Hes1 and inducing scaffold protein JSAP1 in IR‐triggered liver inflammation; our findings underscore the crucial role of the Notch–Hes1 axis as a novel regulator of innate immunity‐mediated inflammation and imply the therapeutic potential for the management of organ IR injury in transplant recipients. (Hepatology 2017).

Source: Hepatology - January 24, 2018 Category: Internal Medicine Authors: Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W. Busuttil, Qi ‐Long Ying, Jerzy W. Kupiec‐Weglinski, Bibo Ke Tags: Liver Injury and Regeneration Source Type: research