Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription.

In conclusion, we demonstrated that a sufficient concentration of Bcl3 in mESCs plays a critical role in the maintenance of pluripotency and the self-renewal of mESCs via the regulation of Nanog transcriptional activity. PMID: 29335071 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29335071?dopt=Abstract

Source: BMB Reports - January 16, 2018 Category: Biochemistry Authors: Kang S, Yun J, Kim DY, Jung SY, Kim YJ, Park JH, Ji ST, Jang WB, Ha J, Kim JH, Baek SH, Kwon SM Tags: BMB Rep Source Type: research