A case of radiation induced osteosarcoma of the skull presenting as a cutaneous epidermotropic tumour with a short latent period

We report a case of a 34 year‐old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, three years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of Temozolomide. The histological features were those of a high‐grade osteosarcoma with epidermotropism of tumor cells. Lymph nodes were partially replaced by high‐grade metastatic osteosarcoma with extra‐nodal lymphatic tumor thrombi. To our knowledge the only other case report of post‐radiation osteosarcoma with a short latency period was a case of osteosarcoma in the craniofacial bone three years after radiotherapy for maxillary squamous cell carcinoma. The histological finding of prominent replacement of the epidermis by osteosarcoma has not been reported before.
Source: Journal of Cutaneous Pathology - Category: Pathology Authors: Tags: CASE REPORT Source Type: research

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CONCLUSION: Our case showed that the immunosuppressed state related to multiple factors such as underlying disease, immunosuppressive therapy and hemodialysis may all have contributed to the development of this neoplastic disorder in our patient. PMID: 30316478 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures.Ocul Oncol Pathol
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
ConclusionsThe treatment landscape for mccRCC has evolved since the introduction of VEGF inhibitors. Combination therapies involving checkpoint inhibitors could be the next standard of care.Patient summaryWith the expanding role of immune checkpoint inhibitors in metastatic renal cell carcinoma, the treatment paradigm has shifted to include combination therapy in the untreated setting. As the field advances, the bar has been raised in evaluating ongoing combination strategies.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractThe purpose of this study is to create a new pseudo-computed tomography (CT) imaging approach under superposed ultrasound (US) deformation fields based on step-by-step local registration. Scanned CT and US 3D image datasets of three patients with postoperative cervical carcinoma were selected, including CT (CTsim) and US images (USsim) acquired during simulated positioning process and cone beam CT (CBCT) and US images for positioning verification (USpv) acquired after treatment for 10 times. Regions of interest such as urinary bladders were segmented out and accepted local registration to obtain different deformati...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
International Journal of Cancer,Volume 0, Issue ja, -Not available-.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
We report a case of a 34‐year‐old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, 3 years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of temozolomide. The histological features were those of a high‐grade osteosarcoma with epidermotropism of tumor cells. Lymph nodes were partially replaced by high‐grade metastatic osteosarcoma, with extra‐nodal lymphatic tumor thrombi. To our knowledge the only other case report of post‐radiation osteosarcoma with a short latency period ...
Source: Journal of Cutaneous Pathology - Category: Pathology Authors: Tags: CASE REPORT Source Type: research
Conclusion: OMMs constitute a significant health burden in our region. Thus, adequate resources should be allocated toward improving awareness among the populace. Policy shifts and regular dental visits which may increase the likelihood of early intervention should be instituted.
Source: Journal of Orofacial Sciences - Category: Dentistry Authors: Source Type: research
Source: Journal of Cutaneous Pathology - Category: Pathology Authors: Tags: Letter to the Editor Source Type: research
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