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Histopathological findings in pregnancy associated cutaneous hyperpigmentation.
Abstract Hyperpigmentation in pregnancy is a common phenomenon, experienced to some degree by up to 90% of pregnant women. It mainly involves sun‐exposed areas, but it can extend to non‐exposed zones. Cases with extensive hyperpigmentation are rarely reported. In this paper, we describe the case of a 30‐year‐old phototype V woman in her 37th week of pregnancy, who presented with brownish hyperpigmentation of the skin in extensive areas, including both axillae, the abdomen, and the lowest part of the back. In the abdomen, there was a reinforcement of the hyperpigmentation through the linea nigra and the umbilicus. T...
Source: Journal of Cutaneous Pathology - January 18, 2018 Category: Pathology Authors: Angel Fernandez ‐Flores, Juan Manuel Barja, Alejandro Vilas‐Sueiro, Antonio Alija Tags: CASE REPORT Source Type: research

Severe and recurrent levamisole ‐induced cutaneous vasculopathy
Abstract Levamisole‐induced vasculopathy is a thrombotic and necrotic vasculitis usually seen in cocaine users due to adulteration of the drug with this veterinary medication. Some cases can be severe or very extensive, which could lead to sepsis and death. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 18, 2018 Category: Pathology Authors: JM Fernandez Armenteros, A Ve à Jódar, C Matas Nadal, C Cortés Pinto, X Soria Gili, RM Martí Laborda, F Vilardell Villellas, JM Casanova Seuma Tags: BRIEF COMMUNICATION Source Type: research

Histological features and outcome of inverted type ‐A melanocytic nevi
Abstract The presence of enlarged epithelioid/spindled nests located deep in the reticular dermis of a biphasic melanocytic neoplasm can mimic melanoma arising in a preexisting nevus, causing over‐interpretation of malignancy. We aimed to define the clinicopathologic significance of epithelioid/spindled nests in melanocytic nevi. Retrospectively using clinical and histologic information, we characterized 121 patients with a single lesion showing epithelioid/spindled melanocytes in the reticular dermis or subcutaneous fat, surrounded by melanophages, sometimes blending in with the adnexa. The majority of nevi occurred in ...
Source: Journal of Cutaneous Pathology - January 17, 2018 Category: Pathology Authors: Soheil S. Dadras, Jun Lu, Artur Zembowicz, Thomas J. Flotte, Martin C. Mihm Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 15, 2018 Category: Pathology Tags: ISSUE INFORMATION Source Type: research

A case of radiation induced osteosarcoma of the skull presenting as a cutaneous epidermotropic tumour with a short latent period
We report a case of a 34 year‐old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, three years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of Temozolomide. The histological features were those of a high‐grade osteosarcoma with epidermotropism of tumor cells. Lymph nodes were partially replaced by high‐grade metastatic osteosarcoma with extra‐nodal lymphatic tumor thrombi. To our knowledge the only other case report of post‐radiation osteosarcoma with a short latency period was a case of...
Source: Journal of Cutaneous Pathology - January 13, 2018 Category: Pathology Authors: E Rashidghamat, E Calonje Tags: CASE REPORT Source Type: research

Primary cutaneous secretory carcinoma: A previously overlooked low ‐grade sweat gland carcinoma
DiscussionPCSC is a rare neoplasm, described in the skin in 2009, that affects more frequently females with a mean age of 42.3 years and it is most commonly located in axilla. Histopathologically, these tumor cells are characterized by bubbly eosinophilic secretions diastase‐resistant and bland nuclei and they are arranged in various growth patterns, including microcystic, tubular, solid and papillary. S100, mammoglobin and CK7 are usually positive. We review the main histopathological features to rule out histopathologic mimics such as breast metastasis, salivary tumors, cribriform carcinoma and primary cutaneous...
Source: Journal of Cutaneous Pathology - January 10, 2018 Category: Pathology Authors: Mar Llamas ‐Velasco, Thomas Mentzel, Arno Rütten Tags: CASE REPORT Source Type: research

Erythema elevatum diutinum with pustule formation: An unusual finding
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 2, 2018 Category: Pathology Authors: Wei Ba, Yi Yang, Liqiang Zheng, Biwen Lin, Zigang Zhao, Chengxin Li Tags: BRIEF COMMUNICATION Source Type: research

Blastic plasmacytoid dendritic cell neoplasm with centrocyte ‐like morphology clinically simulating a melanocytic nevus
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy originating from immature or resting plasmacytoid dendritic cells.(1) Since the most recently revised nomenclature by consensus in 2008 by the World Health Organization (WHO), 21 cases of BPDCN have been reported in the literature. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 2, 2018 Category: Pathology Authors: Christopher Chu, Eric W. Rudnick, Kiran Motaparthi Tags: COVER QUIZLET Source Type: research

Dermatomyositis: histopathologic findings of parakeratosis and dermal edema revisited
We present a case of dermatomyositis with a combination of common and rare skin findings, both clinically and histologically. Increased awareness of papulosquamous and edematous lesions of dermatomyositis can help direct patient care. Although uncommon, confluent parakeratosis and dermal edema can be manifestations of dermatomyositis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 1, 2018 Category: Pathology Authors: Lauren Levy, Heather Layher, Jennifer M. McNiff, Christine J. Ko Tags: CASE REPORT Source Type: research

Lymphangioma circumscriptum of the tongue, a case with marked haemorrhagic component
Abstract Lymphangioma circumscriptum (LC) is considered a superficial variant of lymphangioma with characteristic small lymphatic channels. Diagnosis is routinely made through histopathology in addition to immunostaining. An unusual case of LC presenting as a painless overgrowth of the tongue in a middle‐aged male is reported with emphasis on the clinical and histopathological differential diagnosis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 1, 2018 Category: Pathology Authors: Mohammad S. Alrashdan, Huda M. Hammad, Bayan A. I. Alzumaili, Mohammed Alorjani Tags: CASE REPORT Source Type: research

Septolobular Panniculitis in Disseminated Lyme Borreliosis
We present such a case in a patient who was initially treated for cellulitis as well as neck and radicular leg pain, thereby expanding the cutaneous spectrum of Lyme disease. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 1, 2018 Category: Pathology Authors: Martin Dittmer, Melissa Willis, John Selby, Vincent Liu Tags: CASE REPORT Source Type: research

Red tattoo ‐related mycosis fungoides‐like CD8+ pseudolymphoma
We describe an exceedingly rare case of red tattoo‐related T‐cell predominant pseudolymphoma microscopically mimicking mycosis fungoides. Careful clinicopathological correlation was required to obtain the correct diagnosis and aid in an effective treatment course. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 27, 2017 Category: Pathology Authors: Brian J. King, Julia S. Lehman, William R. Macon, Gabriel F. Sciallis Tags: CASE REPORT Source Type: research

Metastatic serous carcinoma presenting as inflammatory carcinoma over the breast —Report of two cases and literature review
We present 2 patients with history of breast carcinoma and serous carcinoma of ovarian/peritoneal origin that presented with inflammatory carcinoma over the breast. Biopsies from breast tissue showed atypical cells in the dermis forming cords and papillary structures. Histopathologic differential diagnosis included infiltrating ductal carcinoma of breast origin and metastatic serous carcinoma. Immunohistochemical studies showed that the tumor cells were positive for markers of ovarian origin such as PAX‐8 and CA‐125 and negative for breast markers such as GATA‐3, thus supporting the diagnosis. In summary, we describe...
Source: Journal of Cutaneous Pathology - December 26, 2017 Category: Pathology Authors: Gauri Panse, Veerle Bossuyt, Christine J. Ko Tags: CASE REPORT Source Type: research

An incidental finding of an asymptomatic intraneural glomus tumour: a case report and review of the literature
Abstract Glomus tumours are rare, soft‐tissue neoplasms arising from the thermoregulatory neuromyoarterial glomus bodies. They are commonly observed in the extremities and typically present with symptoms of cold hypersensitivity, pain and localised tenderness. Intraneural glomus tumours (INGT) are even rarer. Here we review the literature on INGT and present an unusual case of an asymptomatic, INGT, found incidentally within the excision specimen of a spiradenocarcinoma that arose near the natal cleft. Interestingly, this had not been identified on magnetic resonance imaging (MRI) used to investigate the spiradenocarcino...
Source: Journal of Cutaneous Pathology - December 22, 2017 Category: Pathology Authors: S Muthiah, R Hussain, N Stefanos, A Husain Tags: CASE REPORT Source Type: research

Issue Information
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 19, 2017 Category: Pathology Tags: ISSUE INFORMATION Source Type: research

Insulinoma ‐associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype, the diagnosis can be challenging. Ultimately, immunohistochemistry (IHC) is essential to the definitive diagnosis of MCC and in difficult cases,...
Source: Journal of Cutaneous Pathology - December 17, 2017 Category: Pathology Authors: Patrick S. Rush, Jason N. Rosenbaum, Madhuchhanda Roy, Rebecca M. Baus, Daniel D. Bennett, Ricardo V. Lloyd Tags: ORIGINAL ARTICLE Source Type: research

Pemetrexed ‐induced painful erythematous nodules in both legs in a patient with recurrent mesothelioma
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 14, 2017 Category: Pathology Authors: Mar Llamas ‐Velasco, Enrique Ovejero‐Merino, Javier Fraga, Amaro García‐Diez, Ramón Moreno‐Balsalobre Tags: BRIEF COMMUNICATION Source Type: research

Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review
We report the case of a 53‐year‐old female with an erythematous, papular eruption occurring in association with Hodgkin lymphoma. Histopathological evaluation of the rash confirmed PNGD. To the best of our knowledge, this is the first case of PNGD occurring in association with Hodgkin lymphoma. Although extremely rare, underlying malignancy should be considered in patients with PNGD, particularly in individuals with constitutional symptoms and the absence of an obvious inflammatory etiology. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 11, 2017 Category: Pathology Authors: Jacqueline Deen, Leith Banney, Joanna Perry ‐Keene Tags: CASE REPORT Source Type: research

Spontaneous involution (regression) of a solitary cutaneous myofibroma in an adult patient
This report describes the historical, clinical and histopathological features of adult myofibromas and a novel manifestation that may guide future clinical considerations when approaching solitary tumors with regressive features. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 10, 2017 Category: Pathology Authors: Michael Heath, Tamar Hajar, Vessy Korcheva, Justin Leitenberger Tags: CASE REPORT Source Type: research

Epstein ‐Barr virus positive diffuse large B‐cell lymphoma presenting with vaginal sloughing and ulcerated skin nodule
We report a case of Epstein‐Barr virus associated diffuse large B‐cell lymphoma of the genital tract and skin in a 60‐year‐old woman on long‐term azathioprine. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 10, 2017 Category: Pathology Authors: Lynette Y. Lee, Rama Namuduri, Michelle M. F. Chan, Jeffrey K. S. Quek, Mark J. ‐A. Koh Tags: CASE REPORT Source Type: research

Indolent, waxing and waning cutaneous presentation of HTLV ‐1‐associated adult T‐cell leukemia/lymphoma in an HIV‐1‐positive patient
We present an unusual case of human T‐cell leukemia‐lymphoma virus type 1 (HTLV‐1)‐associated adult T‐cell leukemia/lymphoma in an human immunodeficiency virus (HIV) patient who presented with non‐diffuse, papular, waxing and waning cutaneous eruptions. The patient is a 61‐year‐old Haitian male with history of HIV on highly active antiretroviral therapy (HAART) who presented with multiple painful pink papules on his distal fingers and back for more than a year with a waxing and waning course. Skin biopsy demonstrated a CD4+, CD25+, CD8− lymphocytic proliferation with a clonal T‐cell receptor gene re...
Source: Journal of Cutaneous Pathology - December 10, 2017 Category: Pathology Authors: Justin D. Richey, Benjamin J. Chen, April C. Deng Tags: CASE REPORT Source Type: research

Primary chondro ‐osseous melanoma (chondrosarcomatous and osteosarcomatous melanoma)
We report 3 cases of primary melanoma with extensive bone and cartilage matrix. The first case arose in the nasal mucosa of a 72‐year‐old woman, the second case in the left index finger of a 26‐year‐old woman and the third case in the left cheek of a 68‐year‐old woman. In tumors where osseous and chondroid differentiation appear in mucosa and skin, primary melanoma with chondro‐osteosarcomatous differentiation should be considered in the differential. Careful histological examination together with clinical correlation and ancillary immunohistochemical studies can ensure the correct diagnosis is made. (Source:...
Source: Journal of Cutaneous Pathology - December 6, 2017 Category: Pathology Authors: Ali M. Ali, Wei ‐Lien Wang, Alexander J. Lazar Tags: CASE REPORT Source Type: research

Lymphocytes in Sweet Syndrome: A Potential Diagnostic Pitfall
Abstract Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a distinct clinical‐pathologic entity characterized by an abrupt eruption of tender or painful erythematous or violaceous plaques or nodules, with histopathologic features of a predominantly neutrophilic infiltrate in the dermis without leukocytoclastic vasculitis, constituting the major criteria for the diagnosis (1, 2). Clinically, these present as acutely eruptive juicy, erythematous papules and plaques. SS may be associated with a variety of systemic disorders, including malignancy, medications, and pregnancy. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: Viktoryia Kazlouskaya, Jacqueline M. Junkins ‐Hopkins Tags: ORIGINAL ARTICLE Source Type: research

Genomic analysis of a case of agminated Spitz nevi and congenital ‐pattern nevi arising in extensive nevus spilus
We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital‐pattern compound nevi that underwent genetic analysis to further characterize the mutational profile of this rare entity. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: Caitlin Porubsky, Jamie K. Teer, Yonghong Zhang, Maria Deschaine, Vernon Sondak, Jane L. Messina Tags: CASE REPORT Source Type: research

Contiguous verrucous proliferations in syringocystadenoma papilliferum: a retrospective analysis with additional evaluation via mutation ‐specific BRAF V600E immunohistochemistry
Abstract Syringocystadenoma papilliferum (SCAP) is a benign adnexal neoplasm with apocrine differentiation.1,2 which may be derived from pluripotent cells.3 The lesion may develop within a pre‐existing nevus sebaceus, but the majority of cases arise sporadically.3 Congenital lesions in a Blaschkoid distribution have also been reported, and these cases are thought to represent genetic mosaicism.4,5,6 The tumor has a varied clinical appearance, but typically presents as a raised warty, hairless plaque or nodule.3 (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: BJ Friedman, J Sahu, CC Solomides, DM Connolly, JB Lee Tags: ORIGINAL ARTICLE Source Type: research

Primary cutaneous secretory carcinoma: a previously overlooked low grade sweat ‐gland carcinoma
Abstract Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published; nine of them showed the ETV6‐NTRK3 translocation and an additional case had a heterozygous deletion of ETV6 in 25% of cells (Table 1).1‐7 These cutaneous tumors are related to secretory breast carcinoma (SBC) and mammary analogue secretory carcinoma (MASC) from the salivary glands, with all sharing a balanced chromosomal translocation of t(12;15)(p13;q25) that leads to ETV6‐NTRK3 gene fusion. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: M. Llamas ‐Velasco, T. Mentzel, A. Rütten Tags: CASE REPORT Source Type: research

Metastatic Laryngeal Large Cell Neuroendocrine Carcinoma: A Rare Case of Presentation and Extreme Tumor Burden
We present a case of a 56‐year‐old female who presented with painful subcutaneous skin lesions that were diagnosed as metastatic carcinoma at an outside facility. Subsequent workup revealed a primary epiglottic lesion. Over the next 4 years, she continued to develop over 100 similar subcutaneous nodules. Additional workup confirmed neuroendocrine differentiation, thus clarifying the diagnosis of metastatic large cell neuroendocrine carcinoma. Review of literature has only revealed one reported case of LCNEC with skin metastasis. This is the first reported case whereby skin metastasis was the initial presenting symptom;...
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: Andrew Dunn, Brannon G Broadfoot, Jennifer Hunt, Jennifer R Kaley, Omar Atiq, Narendra Babu Gutta, Xiaofei Wang, Jerad M Gardner, Sara C Shalin Tags: CASE REPORT Source Type: research

Metastatic serous carcinoma presenting as inflammatory carcinoma over the breast – report of two cases and literature review
We present two patients with history of breast carcinoma and serous carcinoma of ovarian/peritoneal origin that presented with inflammatory carcinoma over the breast. Biopsies from breast tissue showed atypical cells in the dermis forming cords and papillary structures. Histopathologic differential diagnosis included infiltrating ductal carcinoma of breast origin and metastatic serous carcinoma. Immunohistochemical studies showed that the tumor cells were positive for markers of ovarian origin such as PAX‐8 and CA125 and negative for breast markers such as GATA‐3, thus supporting the diagnosis. In summary, we describe ...
Source: Journal of Cutaneous Pathology - December 1, 2017 Category: Pathology Authors: Gauri Panse, Veerle Bossuyt, Christine J. Ko Tags: CASE REPORT Source Type: research

Granular cell basal cell carcinoma: a case report
We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields with a Ki‐67 proliferative index approximated at 5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6, and p63 and focal positivity for lysozymes, CD68 (clone KP1) and Bcl‐2. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 28, 2017 Category: Pathology Authors: Xinyi Ma, Guihua Wang, Aditya Kuwadekar, Min Zhao, Weili Hu, Yeqin Wu, Zhongliang Yi, Xianen Xu, Li Xu Tags: CASE REPORT Source Type: research

Nuclear and cytoplasmic features in the diagnosis of Clark's nevi
ConclusionOur data suggest that nuclear alterations have a value in the diagnosis of melanoma. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 28, 2017 Category: Pathology Authors: Manuel Valdebran, Justin Bandino, Amira Elbendary, Abdallah Gad, Sri Krishna Chaitanya Arudra, S ébastien de Feraudy, Dirk M. Elston Tags: ORIGINAL ARTICLE Source Type: research

Presence of Stratum Corneum Serum in Non ‐Palmoplantar Psoriasis
Abstract Psoriasis is a common, chronic, relapsing skin eruption characterized by abnormal hyperproliferation of the epidermis. Clinically, it typically consists of well‐circumscribed erythematous plaques with a silvery white scale in its plaque form, located usually on the extensor surfaces of the extremities, sacral region, scalp and nails. There are a number of clinical variants, including guttate, pustular and erythrodermic psoriasis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 28, 2017 Category: Pathology Authors: S Chahal, B Tallon Tags: ORIGINAL ARTICLE Source Type: research

Red Tattoo Related Mycosis Fungoides ‐like CD8+ Pseudolymphoma
Abstract Cutaneous tattoo reactions are most often seen to red tattoo ink.1 Spongiotic, lichenoid, psoriasiform, granulomatous, and pseudolymphomatous inflammatory reaction patterns have been described.2 Those dyes containing mercury sulfide (cinnabar) are thought to be particularly reactive although the more recently utilized organic red pigments are reactive and can manifest as exuberant delayed hypersensitivity reactions. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 28, 2017 Category: Pathology Authors: Brian J. King, Julia S Lehman, William R Macon, Gabriel F Sciallis Tags: CASE REPORT Source Type: research

In Vivo Reflectance Confocal Microscopy Image Interpretation for the Dermatopathologist
Abstract Reflectance confocal microscopy (RCM) is a technology utilized for bedside diagnosis of cutaneous pathology by non‐invasive, in vivo, cellular‐level imaging. With the recent establishment of reimbursement codes by the US Centers for Medicaid and Medicare Services (CMS), RCM is now likely to be employed by clinical dermatologists and impact decision making on skin cancer management. Dermatopathologists, therefore, would benefit from learning how to interpret RCM images and how RCM findings correlate with histopathological criteria of diagnosis. This review briefly explains the principles behind RCM image acquis...
Source: Journal of Cutaneous Pathology - November 27, 2017 Category: Pathology Authors: Neda Shahriari, Jane M. Grant ‐Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope Tags: REVIEW Source Type: research

Leiomyosarcoma of the great saphenous vein (vena saphena magna) with granular cell change: Report of a superficial neoplasm
The great saphenous vein (GSV) corresponds to the main superficial large‐caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular soft tissue mass. Herein, we report a case on the distal portion of the right GSV of a 57‐year‐old man. The histopathological recognition of a large‐caliber vein‐associated LMS (with granular cell change) in an incisional biopsy specimen was crucial to guide radiological evaluation and confirmation of a superficial vascul...
Source: Journal of Cutaneous Pathology - November 27, 2017 Category: Pathology Authors: Ricardo S. Macarenco, Renee Z. Filippi, Felipe D ’Almeida Costa, Reynaldo Jesus‐Garcia Tags: CASE REPORT Source Type: research

Sampling of Wide Local Excision Specimens in Cutaneous Malignant Melanoma
ConclusionsWe have shown that for WLE specimens with no evidence of a macroscopic lesion and clear margins on original biopsy, little is to be gained from extensive sampling. In these cases we recommend a maximum of 3 blocks per case. Reduction in sampling based on this evidence would result in saving valuable laboratory resources. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 23, 2017 Category: Pathology Authors: Cassie Fives, Cynthia C. B. B. Heffron Tags: ORIGINAL ARTICLE Source Type: research

Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T ‐cell and B‐cell lymphoproliferative disorders
ConclusionsOur clinical scenario analysis and literature review revealed well‐supported clinical scenarios and identified opportunities for additional research to further define the utility of clonality assays in some clinical scenarios. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 22, 2017 Category: Pathology Authors: Nneka Comfere, Uma Sundram, Maria Yadira Hurley, Brian Swick Tags: REVIEW Source Type: research

TNF α and IL‐17A are differentially expressed in psoriasis‐like vs eczema‐like drug reactions to TNFα antagonists
BackgroundTumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema‐like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. The exact pathophysiology is as yet unknown. MethodsA total of 33 patients (19 female, average age 52 years) who had a cutaneous reaction to infliximab, adalimumab or etanercept were included. The type of inflammat...
Source: Journal of Cutaneous Pathology - November 22, 2017 Category: Pathology Authors: Cornelia Deubelbeiss, Antonios G. A. Kolios, Florian Anzengruber, Lars E. French, Nikhil Yawalkar, Werner Kempf, Katrin Kerl, Barbara Meier, Alexander A. Navarini Tags: ORIGINAL ARTICLE Source Type: research

Leukocytoclastic vasculitis presenting in association with Coxiella burnetii (Q fever): A case report
Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41‐year‐old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Workup revealed positive serologic testing for C. burnetii and skin biopsy of the rash revealed leukocytoclastic vasculitis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 20, 2017 Category: Pathology Authors: Stephen S. Koh, Aldon Li, David S. Cassarino Tags: CASE REPORT Source Type: research

INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma)
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging. Ultimately, immunohistochemistry (IHC) is essential to the definitive diagnosis of MCC, and in difficult cases...
Source: Journal of Cutaneous Pathology - November 17, 2017 Category: Pathology Authors: Patrick S. Rush, Jason N. Rosenbaum, Madhuchhanda Roy, Rebecca M. Baus, Daniel D. Bennett, Ricardo V. Lloyd Tags: ORIGINAL ARTICLE Source Type: research

Direct immunofluorescence testing in vasculitis —A single institution experience with Henoch‐Schönlein purpura
BackgroundDirect immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results. MethodsCases submitted for DIF and histology (2010‐2014) with “vasculitis” in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of Henoch‐Schönlein purpura (HSP). Peri/intravascular IgA was considered “positive,” other reactants “non‐specific” and no immunoreactivity “negative.” ResultsVasculitis was the given indication for 20% (258/1318) of DIF studie...
Source: Journal of Cutaneous Pathology - November 8, 2017 Category: Pathology Authors: Patrick Feasel, Steven D. Billings, Wilma F. Bergfeld, Melissa P. Piliang, Anthony P. Fernandez, Jennifer S. Ko Tags: ORIGINAL ARTICLE Source Type: research

Expression of connexin 43 in the human hair follicle: emphasis on the connexin 43 protein levels in the bulge and through the keratinization process
ConclusionsThe bulge contains Cx43. Our results suggest that keratinization in the hair follicle is closely related to the decrease in Cx43 expression. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 2, 2017 Category: Pathology Authors: Angel Fernandez Flores, Adrian Varela ‐Vazquez, Maria D. Mayan, Eduardo Fonseca Tags: ORIGINAL ARTICLE Source Type: research

Expression of connexin43 in the human hair follicle: emphasis on the connexin43 protein levels in the bulge and through the keratinization process
ConclusionsThe bulge contains Cx43. Our results suggest that keratinization in the hair follicle is closely related to the decrease in Cx43 expression. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 2, 2017 Category: Pathology Authors: Angel Fernandez Flores, Adrian Varela ‐Vazquez, Maria D. Mayan, Eduardo Fonseca Tags: ORIGINAL ARTICLE Source Type: research

Pleomorphic mastocytoma in an adult
A cutaneous mastocytoma (CM) is a clinical variant of cutaneous mastocytosis. It is defined as the presence of up to 3 isolated mast cell skin lesions. When only 1 lesion is observed, the patient is classified as having a solitary mastocytoma, and when 4 or more lesions are observed, the patient should be classified as having urticaria pigmentosa (1). (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 1, 2017 Category: Pathology Authors: Vicente Exposito ‐Serrano, Eugenia Agut‐Busquet, Lorena Leal Canosa, Jose Herrerías Moreno, Amparo Saez, Jesús Luelmo Tags: CASE REPORT Source Type: research

Indolent, Waxing and Waning Cutaneous Presentation of HTLV ‐1 Associated Adult T‐cell Leukemia/Lymphoma in an HIV‐1 Positive Patient
Abstract It is well known that patients infected with human immunodeficiency virus type I (HIV‐1) are more likely to develop malignancies such as Kaposi sarcoma, non‐Hodgkin lymphoma, and anal and cervical carcinomas. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 1, 2017 Category: Pathology Authors: Justin D. Richey, Benjamin J. Chen, April C. Deng Tags: CASE REPORT Source Type: research

Epstein ‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma Presenting with Vaginal Sloughing and Ulcerated Skin Nodule
Diffuse large B‐cell lymphoma (DLBCL) is an aggressive non‐Hodgkin lymphoma (NHL) with subtypes that can be distinguished on the basis of clinical, immunophenotypic, morphologic, and molecular characteristics. The genital tract as a primary site for NHL is very rare (1). (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 31, 2017 Category: Pathology Authors: Lynette Ying Lee, Rama Namuduri, Michelle Mei Fung Chan, Jeffrey Kim Siang Quek, Mark Jean ‐Aan Koh Tags: CASE REPORT Source Type: research

Folliculotropic mycosis fungoides presenting with a solitary lesion: clinicopathological features and long ‐term follow‐up data in a series of nine cases
Folliculotropic mycosis fungoides (FMF) is a rare but distinct variant of mycosis fungoides (MF), histologically characterized by the presence of folliculotropic infiltrates, often with sparing of the epidermis, and clinically by the preferential involvement of the head and neck region.1 (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 31, 2017 Category: Pathology Authors: S. van Santen, P.M. Jansen, M.H. Vermeer, R. Willemze Tags: ORIGINAL ARTICLE Source Type: research

Calciphylaxis with Pseudoxanthoma Elasticum ‐like Changes: A Case Series
CONCLUSIONThe presence of PXE‐like changes in the subcutis may heighten suspicion for a diagnosis of calciphylaxis in the appropriate clinical setting and be helpful when classic histologic features are subtle or absent. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 31, 2017 Category: Pathology Authors: Lauren A. Penn, Nooshin Brinster Tags: ORIGINAL ARTICLE Source Type: research

Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and Factor XIIIa to the rescue?
In this issue of the Journal of Cutaneous Pathology, Tjarks et al. present a study that advances our understanding of the diagnosis of sebaceous neoplasms (in particular, sebaceous carcinoma) and the lesions that mimic them (1). (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 31, 2017 Category: Pathology Authors: Michael T. Tetzlaff Tags: PERSPECTIVES IN DERMATOPATHOLOGY Source Type: research

Views of Dermatopathologists about Clonality Assays in the Diagnosis of Cutaneous T cell and B cell Lymphoproliferative Disorders
ConclusionsOur clinical scenario analysis and literature review revealed well supported clinical scenarios and identified opportunities for additional research to further define the utility of clonality assays in some clinical scenarios. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 30, 2017 Category: Pathology Authors: Nneka Comfere, Uma Sundram, M. Yadira Hurley, Brian Swick Tags: REVIEW Source Type: research

Spontaneous Involution (Regression) of a Solitary Cutaneous Myofibroma in an adult patient: Case Report
This report describes the historical, clinical, and histopathological features of adult myofibromas and a novel manifestation that may guide future clinical considerations when approaching solitary tumors with regressive features. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 28, 2017 Category: Pathology Authors: Michael Heth, Tamar Hajar, Vessy Korcheva, Justin Leitenberger Tags: CASE REPORT Source Type: research