MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status [ADULT BRAIN]

CONCLUSIONS:
MR elastography demonstrated that not only were gliomas softer than normal brain but the degree of softening was directly correlated with tumor grade and IDH1-mutation status. Noninvasive determination of tumor grade and IDH1 mutation may result in improved stratification of patients for different treatment options and the evaluation of novel therapeutics. This work reports on the emerging field of "mechanogenomics": the identification of genetic features such as IDH1 mutation using intrinsic biomechanical information.

Source: American Journal of Neuroradiology - January 11, 2018 Category: Radiology Authors: Pepin, K. M., McGee, K. P., Arani, A., Lake, D. S., Glaser, K. J., Manduca, A., Parney, I. F., Ehman, R. L., Huston, J. Tags: ADULT BRAIN Source Type: research