Lyme Borreliosis in Children: A Tertiary Referral Hospital–Based Retrospective Analysis

This study aims to estimate the incidence of LB among children with a clinical suspicion for Lyme in a tertiary referral center in the Netherlands. Patient chart data on medical history, clinical signs and symptoms, diagnostic test results and diagnoses were collected using standardized case record forms. Patients were categorized based on clinical and laboratory findings using a modified, previously published classification system. We included 325 children, with a median age of 11.9 years, of whom 61.8% were female. LB was diagnosed in 38 of the referred children (11.7%). However, of the 85 patients who were specifically referred to the Lyme clinic, 28 (32.9%) were diagnosed with LB. Of the specifically referred Lyme-positive patients, 11 (39.3%) had a definitive LB diagnosis. Twelve children had a posttreatment LB syndrome. In line with previous reports in adults, only a small proportion of children referred with a suspicion of LB were diagnosed with definite or probable LB, which illustrates the difficulty in diagnosing LB by the general practitioner or pediatrician in a district hospital.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research

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AbstractBackgroundThe clinical course of children with advanced heart block secondary to Lyme disease has not been well characterized.ObjectiveTo review the presentation, management, and time to resolution of heart block due to Lyme disease in previously healthy children.MethodsAn IRB approved single-center retrospective study was conducted of all patients  
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
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Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
This study assessed cost-effectiveness of a potential anti-tick vaccine that would protect against both Lyme borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting of Slovenia.A Markov model was developed to estimate cost-effectiveness of a vaccine with potential combined protection against LB and TBE from the societal perspective. The model expressed time in annual cycles, followed a target population through their lifetime, and applied an annual discounting of 3%. A target population entered the model in a susceptible state, with time dependent probabilities to acquire LB/TBE. Disease manifestatio...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: CME Review Article Source Type: research
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Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
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Source: Topics in Companion Animal Medicine - Category: Veterinary Research Authors: Tags: Research Article Source Type: research
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Source: WMJ - Category: General Medicine Authors: Tags: WMJ Source Type: research
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