Genes and pathways regulated by androgens in human neural cells, potential candidates for the male excess in autism spectrum disorders

Prenatal exposure to androgens during brain development in males may participate to increase their susceptibility to develop neurodevelopmental disorders (ND) such as autism spectrum disorders (ASD) or intellectual disability (ID). However, little is known about the action of androgens in human neural cells. Methods: We used human neural precursors (hNSCs) differentiated from embryonic stem cells to investigate targets of androgens.

Source: Biological Psychiatry - January 9, 2018 Category: Psychiatry Authors: Ang élique Quartier, Laure Chatrousse, Claire Redin, Céline Keime, Nicolas Haumesser, Anne Maglott-Roth, Laurent Brino, Stéphanie Le Gras, Alexandra Benchoua, Jean-Louis Mandel, Amélie Piton Tags: Priority Communication Source Type: research