MERS antibodies produced in cattle safe, treatment well tolerated in phase 1 trial
(NIH/National Institute of Allergy and Infectious Diseases) An experimental treatment developed from cattle plasma for Middle East respiratory syndrome (MERS) coronavirus infection shows broad potential, according to a small clinical trial led by National Institutes of Health scientists and their colleagues. The treatment, SAB-301, was safe and well tolerated by healthy volunteers, with only minor reactions documented.
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Mario Rothbauer, Verena Charwat, Barbara E.M. Bachmann, Drago Sticker, Richard Novak, Heinz Dieter Wanzenboeck, Richard A. Mathies, Peter Ertl Microfluidic study of transient cell-to-cell interaction cascades as a response to circulating factors during Type 1 allergic reactions are still in its infancy. Here, we report a fully-automated, miniaturized and... The content of this RSS Feed (c) The Royal Society of Chemistry
Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, et al. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med 2018;379:1991-2001.
Conditions: Enterobacteriaceae Infections; Community-Acquired Infections; Healthcare Associated Infection Intervention: Sponsors: University of North Carolina, Chapel Hill; National Institute of Allergy and Infectious Diseases (NIAID) Enrolling by invitation
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes a highly lethal pulmonary infection with ~35% mortality. Currently there are no prophylactic measures or effective therapies. Inventors at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases have identified and developed neutralizing monoclonal antibodies (nMAbs) against the MERS-CoV. This invention describes antibodies that target the Spike (S) glycoprotein on the coronavirus surface, which mediates viral entry into host cells. These novel antibodies target different regions of the S protein, and when administered in combin...
Coronaviruses (CoVs) can cause severe respiratory disease with high fatality rates in humans. The 2002-2003 SARS-CoV epidemic resulted in 8098 cases and 744 deaths, and MERS-CoV, which emerged in 2012, has resulted in 2144 cases and over 750 deaths as of March 2018. Currently, there are no effective prophylactic or therapeutic measures, and because other CoVs are poised to emerge as new human pathogens, there is a need to define a general CoV vaccine solution. Past efforts to develop CoV vaccines have used whole-inactivated virus, live-attenuated virus, recombinant protein subunit, or genetic approaches.CoV spike (S) prote...
(NIH/National Institute of Allergy and Infectious Diseases) New research published in Cell Reports from scientists at the National Institute of Allergy and Infectious Diseases (NIAID) shows how MERS-CoV can adapt to infect cells of a new species, which suggests that other coronaviruses might be able to do the same.
CONCLUSION: Compounds V and VI were demonstrated viral inhibition towards Human cytomegalovirus, whereas cyclopropylquinoline derivative IV towards Rift Valley fever virus and Tacaribe virus. Additionally, cyclopropylquinoline derivative IV has displayed very good cytotoxicity against colon, breast and leukemia cell lines in vitro. PMID: 29792154 [PubMed - as supplied by publisher]
(NIH/National Institute of Allergy and Infectious Diseases) Enrollment has begun in an early-stage clinical trial testing the safety of two human monoclonal antibodies (mAbs) designed to treat people infected with Middle East respiratory syndrome coronavirus (MERS-CoV). The trial is sponsored by the National Institute of Allergy and Infectious Diseases, part of NIH, and is funded in part by the Biomedical Advanced Research and Development Authority, part of the Office of the Assistant Secretary for Preparedness and Response, Department Health and Human Services.
(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues report that an experimental vaccine given six weeks before exposure to Middle East respiratory syndrome coronavirus (MERS-CoV) fully protects rhesus macaques from disease. The vaccine also generated potentially protective MERS-CoV antibodies in blood drawn from vaccinated camels. MERS-CoV, which causes pneumonia deep in the lungs, emerged in 2012 and has sickened more than 1,400 people and killed 500, mostly in the Middle East and Asia.
Antibody against MERS Transmission EM of MERS-CoV. Image courtesy of National Institute of Allergy and Infectious Diseases. Middle East Respiratory Syndrome (MERS) is a severe infection of the lower respiratory tract caused by the MERS coronavirus (MERS-CoV), which has been responsible for over 1,300 human infections and 500 deaths since...