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MERS antibodies produced in cattle safe, treatment well tolerated in phase 1 trial

(NIH/National Institute of Allergy and Infectious Diseases) An experimental treatment developed from cattle plasma for Middle East respiratory syndrome (MERS) coronavirus infection shows broad potential, according to a small clinical trial led by National Institutes of Health scientists and their colleagues. The treatment, SAB-301, was safe and well tolerated by healthy volunteers, with only minor reactions documented.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Aguilera-Insunza R, Venegas LF, Iruretagoyena M, Rojas L, Borzutzky A Abstract INTRODUCTION: The prevalence of peanut allergy (PA) has increased, affecting approximately 1.1% of children in Western countries. PA causes life-threatening anaphylaxis and frequently persists for life. There are no standardized curative therapies for PA, and avoidance of peanuts remains the main therapeutic option. A better understanding of the pathogenesis of PA is essential to identify new treatment strategies. Intestinal dendritic cells (DCs) are essential in the induction and maintenance of food tolerance because they prese...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Oncology, Ophthalmology, Orthopedics, ENT, Pathology Source Type: news
Allergy, EarlyView.
Source: Allergy - Category: Allergy & Immunology Authors: Source Type: research
Pediatric Allergy and Immunology, EarlyView.
Source: Pediatric Allergy and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Pediatric Allergy and Immunology, EarlyView.
Source: Pediatric Allergy and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Labrada Nutrition of Houston, TX, is recalling specific lots of its " LeanPro8 " Protein Powder because they may contain undeclared egg protein. People who have allergies to egg protein run the risk of serious or life-threatening allergic reaction if they consume these products.
Source: Food and Drug Administration - Category: Food Science Source Type: news
Guideway Care will be entering into a guidance partnership with UAB Medicine for patients with chronic obstructive pulmonary disease, or COPD. Financial terms of the deal were not disclosed.  “We know from previous experience at UAB in the realm of cancer care that lay navigators can improve access, coordinate care delivery and reduce costs for the health system,” said Anand Iyer, assistant professor in the UAB Division of Pulmonar y, Allergy, and Critical Care Medicine. “COPD is one of…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues report that an experimental vaccine given six weeks before exposure to Middle East respiratory syndrome coronavirus (MERS-CoV) fully protects rhesus macaques from disease. The vaccine also generated potentially protective MERS-CoV antibodies in blood drawn from vaccinated camels. MERS-CoV, which causes pneumonia deep in the lungs, emerged in 2012 and has sickened more than 1,400 people and killed 500, mostly in the Middle East and Asia.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Antibody against MERS Transmission EM of MERS-CoV. Image courtesy of National Institute of Allergy and Infectious Diseases. Middle East Respiratory Syndrome (MERS) is a severe infection of the lower respiratory tract caused by the MERS coronavirus (MERS-CoV), which has been responsible for over 1,300 human infections and 500 deaths since...
Source: Proceedings of the National Academy of Sciences - Category: Science Tags: This Week in PNAS Source Type: research
(NIH/National Institute of Allergy and Infectious Diseases) A two-step regimen of experimental vaccines against MERS prompted immune responses in mice and rhesus macaques, report NIH scientists. Vaccinated mice produced broadly neutralizing antibodies against multiple strains of the MERS coronavirus, while vaccinated macaques were protected from severe lung damage when later exposed to MERS-CoV. The findings suggest that the current approach, in which vaccine design is guided by an understanding of structure of viral components and their interactions with host cells, holds promise for developing a similar human MERS vaccine regimen.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
More News: Allergy | Allergy & Immunology | Clinical Trials | Coronavirus | Infectious Diseases | MERS | Middle East Health | National Institutes of Health (NIH) | Respiratory Medicine