Circulating Anti ‐Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts

Abstract A strong positive association has been observed between circulating anti‐Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case‐control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on age at blood donation. AMH was measured using a high sensitivity enzyme‐linked immunoabsorbent assay. Conditional logistic regression was applied to the aggregated dataset. There was a statistically significant trend of increasing breast cancer risk with increasing AMH concentration (ptrend across quartiles 
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research

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Authors: Cui W, Stern C, Hickey M, Goldblatt F, Anazodo A, Stevenson WS, Phillips KA Abstract Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
A lot of people are very worried whether IVF is safe or not, and many infertile couples are not allowed to do IVF by their family members, because they are concerned about the side effects of IVF - both on the mother , and the baby. After all, they believe that in an IVF cycle we're pumping the mother full of powerful hormonal injections – surely these are going to have some adverse effects on the body.Thus, many people believe that these hormones increase the risk of breast cancer and ovarian cancer ; or that an IVF patient will run out of eggs faster and become menopausal sooner, because the IVF cycle “ uses ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Breast cancer affects 1 in every 8 women during their lives, and is the second most common kind of cancer in women. No one knows why some women get breast cancer, but there are many risk factors. Risks that you cannot change include: Age – the risk rises as you get older. Genes – two genes, BRCA1 and BRCA2, greatly increase the risk. Women who have family members with breast or ovarian cancer may wish to be tested for the genes. Personal factors – beginning periods before age 12 or going through menopause after age 55. For the month of October, help save lives in your community by sharing quality h...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Consumer Health Source Type: news
Abstract Women carriers of mutations in the genes BRCA1 and BRCA2 coding for tumor suppressor proteins are at high risk of developing breast and ovarian cancers. Hereditary breast and ovarian cancers due to BRCA pathogenic mutations occur at earlier ages: mean age 43 years at diagnosis of breast cancer for BRCA1 mutations; onset of ovarian cancer up to 10-21% by age 50 years. Preventive strategies are then defined in the reproductive years. The National Comprehensive Cancer Network (NCCN) guidelines define that BRCA1/2 genetic testing should begin with the affected cancer individual (BRCA1/2 full seq...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Abstract OBJECTIVE: The established link between estrogen and breast cancer occurs via both estrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including estrogen catechols and quinones, which have been linked to breast carcinogenesis in post-menopausal women. We aimed to assess if the route of administration of 17β estradiol (E2 ) affects the accumulation of genotoxic estrogen metabolites in a model of ovarian failure in young girls with Turner Syndrome. METHODS: Stored plasma samples obtained at 0 and 12 months were used from 40 ...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Endocrinol (Oxf) Source Type: research
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionAMH levels were decreased in both natural and premature postmenopausal women and could be used as predictor of menopause among women with autoimmune thyroiditis.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: Available online 28 March 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Irene Zolfaroli, Juan J. Tarín, Antonio CanoAbstractEvidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes.Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the chan...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Abstract Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
ConclusionAMH levels were decreased in both natural and premature postmenopausal women and could be used as predictor of menopause among women with autoimmune thyroiditis.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
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