Circulating Anti ‐Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts

Abstract A strong positive association has been observed between circulating anti‐Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case‐control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on age at blood donation. AMH was measured using a high sensitivity enzyme‐linked immunoabsorbent assay. Conditional logistic regression was applied to the aggregated dataset. There was a statistically significant trend of increasing breast cancer risk with increasing AMH concentration (ptrend across quartiles 
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research

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We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionAMH levels were decreased in both natural and premature postmenopausal women and could be used as predictor of menopause among women with autoimmune thyroiditis.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: Available online 28 March 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Irene Zolfaroli, Juan J. Tarín, Antonio CanoAbstractEvidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes.Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the chan...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Abstract Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
ConclusionAMH levels were decreased in both natural and premature postmenopausal women and could be used as predictor of menopause among women with autoimmune thyroiditis.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: Available online 28 March 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Irene Zolfaroli, Juan J. Tarín, Antonio CanoAbstractEvidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes.Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the chan...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions We concluded that different races/ethnicities had different breast cancer related reproductive risk factors. Non-Hispanic Caucasians had the most breast cancer related reproductive risk factors, while the minorities had none or few breast cancer related reproductive risk factors and among these few factors only 1 was also risk factor for non-Hispanic Caucasians.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
290Objectives:Introduction: Significant variations of SUVs and textural indices (TI) as a function of age in non-pathological breast tissue (NBT) have been reported and it has been suggested that this should be accounted for in future radiomic models assessing BC patients (Boughdad et al, JNM 2017;58;S1:470). It is also known that radiomic features vary according to the acquisition and reconstruction protocols. Our goal was to determine whether we could still detect the variations as a function of age when pooling data from two different centers and correcting the center-effect using a recently described harmonization Meth...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Harmonization and standardization for multicenter studies Source Type: research
CONCLUSIONS: Currently, there is insufficient high-quality evidence to inform women considering HRT after treatment for endometrial cancer. The available evidence (both the single RCT and non-randomised evidence) does not suggest significant harm, if HRT is used after surgical treatment for early-stage endometrial cancer. There is no information available regarding use of HRT in higher-stage endometrial cancer (FIGO stage II and above). The use of HRT after endometrial cancer treatment should be individualised, taking account of the woman's symptoms and preferences, and the uncertainty of evidence for and against HRT use. ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Elisa Long was 33 years old and new to the UCLA Anderson faculty when her research and her life grimly intersected. Specializing in medical decision making under uncertainty, she routinely studied how to weigh difficult decisions, often in the absence of complete information. Newly diagnosed with breast cancer — she would soon learn that she is also a BRCA1 mutation carrier — Long was confronted with a critical dilemma of her own: How long could she delay prophylactic surgery to remove healthy organs and still avoid further cancer and risk to her life?Up to 65 percent of women with BRCA1 gene mutations and 45 p...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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