Novel 18F-Labeled {kappa}-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates

Conclusion: The evaluation of 18F-LY2459989 in nonhuman primates demonstrated many attractive imaging properties: fast tissue kinetics, specific and selective binding to the KOR, and high specific binding signals. A side-by-side comparison of 18F-LY2459989 and 11C-LY2459989 indicated similar kinetic and binding profiles for the 2 radiotracers. Taken together, the results indicated that 18F-LY2459989 appears to be an excellent PET radiotracer for the imaging and quantification of the KOR in vivo.

Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Li, S., Cai, Z., Zheng, M.-Q., Holden, D., Naganawa, M., Lin, S.-F., Ropchan, J., Labaree, D., Kapinos, M., Lara-Jaime, T., Navarro, A., Huang, Y. Tags: Basic Source Type: research