Analysis of key GO terms and KEGG pathways associated with carcinogenic chemicals.

In this study, we tried to partly describe the differences between carcinogenic and non-carcinogenic chemicals using gene ontology (GO) terms and KEGG pathways. The carcinogenic and non-carcinogenic chemicals that were retrieved from Carcinogenic Potency Database (CPDB) were encoded into numeric vectors using the enrichment theories of GO terms and KEGG pathways. Then, the minimal redundancy maximal relevance (mRMR) method was adopted to analyze all features, resulting in some important GO terms and KEGG pathways. The extensive analysis of the identified GO terms and KEGG pathways indicate that they all play roles during the tumorigenesis, inducing that they can be key indicator for identification of carcinogenic chemicals. PMID: 29256346 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research