Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction

This article discusses the differences between troponin fragments immunoreactivity to the development of cTnI determination tests, such as the high-sensitivity tests, which arise with the proposal of guaranteeing greater efficiency in the AMI associated diagnosis.RESUMO Entre as doen ças cardiovasculares (DCV), o infarto agudo do miocárdio (IAM) atualmente é considerado a causa mais comum de morte e incapacidade em todo o mundo. Vários testes laboratoriais vêm sendo desenvolvidos para a detecção de lesões cardíacas, entre eles, as troponinas, consideradas marcador (biom arcador sugestivo) padrão-ouro de lesão miocárdica. A alta especificidade da troponina para a necrose dos cardiomiócitos está relacionada com a sequência peptídica única presente na troponina do músculo cardíaco. Em função disso, estudos estão voltados para o desenvolvimento de conjunto s diagnósticos de alta sensibilidade para a determinação das troponinas I (hs-cTnI). Esses conjuntos diagnósticos surgem com o objetivo de detectar concentrações séricas cada vez menores desses biomarcadores a partir da detecção de fragmentos peptídicos que são liberados após modificaçõ es bioquímicas estruturais. O presente artigo discorre sobre as diferenças de imuno...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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By WILLIAM H. BESTERMANN JR., MD New Scientific Breakthroughs Can Provide a Longer Healthier Life Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs
Once again, this issue of Neurology® Neuroimmunology &Neuroinflammation (N2) highlights the diversity of the field with studies on a range of clinical disorders and a variety of research approaches. Optic neuritis in patients with neuromyelitis optica spectrum disorders associated with aquaporin 4 antibodies (AQP4) or myelin oligodendrocyte glycoprotein (MOG) antibodies is considered steroid responsive, although patients can accumulate disability with recurrent attacks. For these patients, Stiebel-Kalish et al.1 investigated whether the time from symptom onset to steroid treatment affected outcome. This was a retro...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Editor ' s Corner Source Type: research
Publication date: Available online 2 July 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Jan Mican, Martin Toul, David Bednar, Jiri DamborskyAbstract:Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used for their treatment. Improving the effectiveness of thrombolytics for clinical uses is of great interest. The knowledge of the multiple roles of the endogenous thrombolytics and the fibrinolytic system grows continuously. The effects of thrombolytics on the alterat...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionThese results demonstrated that progressive nephropathy in MI rats was associated with intrarenal activation of the renin-angiotensin-aldosterone system. Concomitantly, this process was associated with oxidative stress and impaired Nrf2 activation. The improvement in the severity of nephropathy by XJEK in this model may be associated with the reversal of these abnormalities.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
d Anwarul Hasan Heart attack is one of the leading causes of human death worldwide. Every year, about 610,000 people die of heart attack in the United States alone—that is one in every four deaths—but there are well understood early symptoms of heart attack that could be used to greatly help in saving many lives and minimizing damages by detecting and reporting at an early stage. On the other hand, every year, about 2.35 million people get injured or disabled from road accidents. Unexpectedly, many of these fatal accidents happen due to the heart attack of drivers that leads to the loss of control o...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
CONCLUSION: These results demonstrated that progressive nephropathy in MI rats was associated with intrarenal activation of the renin-angiotensin-aldosterone system. Concomitantly, this process was associated with oxidative stress and impaired Nrf2 activation. The improvement in the severity of nephropathy by XJEK in this model may be associated with the reversal of these abnormalities. PMID: 31228798 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Myocardial infarction (MI) is identified as one of the major causes of mortality and disability worldwide. For severe myocardial infarction, even advanced forms of clinical intervention often lead to unsatisfactory therapeutic results. Thus, alternative strategies for MI treatment are still desirable. Previously studies reported the capacity of degradative fragment of h-HA (high molecular weight hyaluronic acid), hyaluronan oligosaccharides (
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
This study aimed to explore the potential role of CKIP-1 in regulating hypoxia-induced cardiomyocyte injury and reveal the underlying mechanism. The results demonstrated that hypoxia-exposed cardiomyocytes showed lower CKIP-1 expression. CKIP-1 restoration by transfecting a CKIP-1 expression vector significantly improved viability and reduced apoptosis in hypoxia-treated cardiomyocytes. Moreover, CKIP-1 overexpression suppressed hypoxia-induced oxidative stress in cardiomyocytes. Mechanism research revealed that CKIP-1 overexpression reduced the expression of kelch-like ECH-associated protein 1 (Keap1) and increased the nu...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Resumo O objetivo foi investigar as associa ções da incapacidade em três níveis (ABVD, AIVD e mobilidade) com doenças cardiovasculares, diabetes e multimorbidade, entre idosos residentes na Região Metropolitana de Belo Horizonte (RMBH). Estudo transversal em amostra representativa de adultos da RMBH, tendo sido selecionados 2.172 idosos (60 anos ou mais). A incapacidade, para cada domínio (ABVD, AIVD e mobilidade), foi avaliada como o relato de muita dificuldade ou necessidade de ajuda para realizar pelo menos uma atividade entre as investigadas, e as doenças autorrefe...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
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