Autophagy in endometriosis.

Autophagy in endometriosis. Am J Transl Res. 2017;9(11):4707-4725 Authors: Yang HL, Mei J, Chang KK, Zhou WJ, Huang LQ, Li MQ Abstract Endometriosis (EMS) is a common gynecologic disease that causes chronic pelvic pain, dysmenorrhea, and infertility in women. The doctrine of menstruation back flow planting and defects in the immune system are well known and widely accepted. In recent years, increasing studies have been focused on the role of autophagy in EMS, and have shown that autophagy plays a vital role in EMS. Autophagy, which is known as the non-apoptotic form of programmed cell death induced by a large number of intracellular/extracellular stimuli, is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles in eukaryotic cells. Autophagy commonly refers to macroautophagy, which is characterized by autophagosomes (double-membrane vesicles). In normal endometrial tissues, autophagy is induced in glandular epithelial and stromal cells throughout the menstrual cycle. However, aberrant autophagy occurs in the eutopic endometrium and ectopic endometriotic foci, which contributes to the pathogenesis of EMS by promoting the hyperplasia of endometriotic tissues and stromal cells, restricting apoptosis, and inducing abnormal immune responses. Consistent with changes in autophagy levels between normal endometria, eutopic and ectopic endometria from patients with EMS, the altered expression of autophagy-related genes (AT...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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Publication date: November 2019Source: International Journal of Industrial Ergonomics, Volume 74Author(s): Trond Kongsvik, Øyvind Dahl, Ingunn Marie Holmen, Trine ThorvaldsenAbstractFew studies have explored the potential connection between safety climate and health issues. However, some recent research findings indicate that a poor safety climate can be considered a stressor that may be associated with physical symptoms and musculoskeletal complaints. This link is further explored in the present study on the basis of a questionnaire study of 446 sharp-end workers in the Norwegian aquaculture industry. The analysis ...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
Publication date: January 2020Source: Urology Case Reports, Volume 28Author(s): Yassine Ayari, Hamza Boussaffa, Ahmed Sellami, Selim Zaghbib, Ben Rhouma Sami, Yassine NouiraAbstractUrinary bladder endometriosis as a part of deep infiltrating pelvic endometriosis is well known, but isolated bladder involvement is very rare. A 36-year-old woman, who had two cesarean sections, was complaining of dysuria, frequency and burning micturition. MRI showed a tissular mass probably originating from the cervix and suggestive of a sarcoma. Cystoscopy identified a nodular bluish retro trigonal mass, which was completely resected. Histop...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conclusions Surgical repair with muscle flap coverage, with or without ligation of profunda femoris artery, does not affect prognosis. An alternative method for identifying healthy segments of femoral artery may be frozen section and examination of the artery to decrease the risk of recurrence at the site of anastomosis.RESUMO Contexto A doen ça de Behçet (DB) é uma enfermidade autoimune que envolve múltiplos sistemas. A manifestação arterial mais comum em pacientes com DB é o pseudoaneurisma, que tem uma frequência mais alta do que a formação de aneurism...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Resumo A s índrome da congestão pélvica (SCP) é definida como dor pélvica crônica há mais de 6 meses associada a varizes perineais ou vulvares, resultantes do refluxo ou obstrução das veias gonadais, glúteas ou periuterinas. A SCP é responsável por 16-31% dos casos de dor pélvica crônica, sendo d iagnosticada sobretudo na terceira e quarta décadas de vida. Nos últimos anos, houve um interesse maior nessa patologia por parte dos cirurgiões vasculares devido à sua associação com insufici&e...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Introduction Exercise therapy (ET) is advocated as a treatment for chronic nonspecific low back pain (CNSLBP). However, therapy effect sizes remain low. In other chronic disorders, training at higher intensity has resulted in greater improvements on both general health related and disease specific outcomes compared to lower-intensity ET. Possibly, high-intensity training also improves effect sizes in CNSLBP. Objective To compare the effects of a high-intensity ET program with a similar moderate-intensity ET program on disability, pain, function, exercise capacity, and abdominal/back muscle strength in persons with CNS...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
When surgeons cut their prescribing of opioids for pain by more than 50%, their patient-satisfaction scores didn't suffer, a small U.S. study found.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Anesthesiology News Source Type: news
AbstractThe aim of the study was to compare CE-MRV with DANTE-SPACE on a 1.5T MRI system for the diagnosis of DVT. The patients were diagnosed with deep venous thrombosis of the lower extremities based on swelling, pain, and superficial varicose veins of the lower extremities. MRI examination confirmed the diagnosis. DANTE-SPACE images were obtained before the conventional contrast-enhanced MRV, which uses gadolinium. The scanning field started from the end of the inferior vena cava to the end of the ankle, divided into five observation segments, namely, the common iliac vein, external iliac vein, femoral vein, popliteal v...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
When my first period came at age 13, it involved blood clots and extreme pain. I didn’t know what to expect or what was considered “normal,” but thankfully, my mother did. She recognized that my symptoms were unusual and immediately took me to see my pediatrician. I was first prescribed birth control pills, which seemed to help initially, but when my period remained heavy and painful, I was put on a different birth control pill that enabled me to have my period only four times a year. I thought my situation was normal – albeit uncomfortable and inconvenient. No one ever suggested that painful period...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories Teen Health endometriosis Marc Laufer Source Type: news
Despite what a carefree tampon commercial would have you believe, that time of the month can be uncomfortable, varied and complex. No two periods look the same: Some women experience excruciating symptoms each time. Others may skip months entirely. And did you know that men can also have a physical reaction to a woman’s monthly cycle? Basically, there’s more to a period than what you hear in pop culture. And it will serve everyone better to be more informed about the process and armed with the facts. Below are a few things everyone should know about that oh-so-wonderful time of the month: 1. The ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Endometriosis has always been a tricky problem . We still don't understand who gets endometriosis ; what causes it; and why there is such little correlation between the extent of the disease and their patient's symptoms. There are still lots of unresolved questions, which is why there are so many controversies about the impact of endometriosis on fertility . This is why patients with endo are so confused about which is the right treatment for them. After all , if doctors are confused , it is highly likely that patients are going to be completely perplexed as well . This is why patients find that they get diametrically oppo...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
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