Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies

We describe advances in genetics, blood-based biomarkers, functional imaging, and systemic therapy of advanced NETs and discuss results of recent phase 3 studies, systemic treatment of advanced disease with peptide receptor radionuclide therapy, biotherapy, chemotherapy, and molecularly targeted therapy, and the potential role of immunotherapy in the treatment of NETs. Suggested treatment algorithms for NETs of ileal or jejunal origin and of pancreatic origin are presented.
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research