Analysis of potential interactions between vitamins D and C using gene expression profiles from mouse models.
This study is to investigate how VD and VC interact at molecular level using whole genome expression profiles from spleens of 111 mouse strains and livers from 40 mouse strains. We first identified the genes that are closely correlated to vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo). We next analyzed the potential molecular pathways of Vdrand Lgo correlated genes and examined how these two sets of pathways are connected in liver and spleen. Our results indicated that Vdrand Lgo associate to distinct groups of genes. While most of genes are not the same, a few of them are associated to both Vdrand Lgo. Our gene network construction suggests that there are interactions between Vdrand Lgopathways. Our work laid down the foundation for future study of the interactions between VD and VC and revealed the potential bias when using animals for the study of VD or VC, as humans do not produce VC. PMID: 29208176 [PubMed - in process]
CONCLUSIONS: Perceived devaluation was extremely prevalent among street-involved youth in our sample. We also observed that youth most in need of health and social services were significantly more likely to report high levels of perceived devaluation which may result in a reluctance to seek out key services and supports. These findings highlight the need to implement stigma reduction interventions for vulnerable youth in this setting. PMID: 30526206 [PubMed - as supplied by publisher]
Conclusion/importance: This work is significant in expanding the populations thought to be impacted by and understanding social disparities related to SC use. Further investigation is needed to assess the relationship between concomitant use of SC and other drug, particularly opiates. This may suggest that the sequelae of one drug may enhance or alleviate the effects of the other. PMID: 30526203 [PubMed - as supplied by publisher]