FPS-ZM1-induced blocking of RAGE alleviates elastase-induced emphysema development by preventing RAGE-DAMP-Nrf2 signaling

Conclusions: Our data indicated for the first time that RAGE inhibition has an essential protective role in COPD. Our observation provided new insight into the therapeutic target in emphysema/COPD.Acknowledgments: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (NRF-2014R1A2A2A01003737)

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lee, H., Heo, H.-R., Kim, J. Y., Kim, W. J., Hong, S.-H., Yang, S.-R. Tags: Mechanisms of Lung Injury and Repair Source Type: research