Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique.

Conclusions: Interstitial brachytherapy for orbit using this innovative technique is a safe and effective modality of local treatment for appropriately selected orbital soft tissue tumors. Brachytherapy resulted in excellent disease control with significant reduction of dose to surrounding ocular structures compared to EBRT. PMID: 29204167 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Related Links:

Soft tissue sarcomas comprise approximately 7.4% of all pediatric malignancies, with rhabdomyosarcoma being the most common soft tissue sarcoma in children. Two thirds of cases arise in children under 10 years of age, and it can arise virtually in any part of the body with two main histological subtypes (alveolar and embryonal).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research
Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. In pediatric malignancies, in particu...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused byPAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed humanPAX3-FOXO1 -driven zebrafish models of tumorigenesis and found thatPAX3-FOXO1 exhibits discrete cell lineage susceptibility and transformation. Tumors developed by 1.6 –19 months and were primitive neuroectodermal tumors or rhabdomyosarcoma. We applied thisPAX3-FOXO1 transgenic zebrafish model to study howPAX3-FOXO1 leverages early developmental pathways for oncogenesis and found thather3 is a unique target. Ectopic expression of theher3 hu...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Developmental Biology and Stem Cells Source Type: research
Cancer, EarlyView.
Source: Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsOur results suggest that androgens sustain and improve RMS transformed and radioresistant phenotype, and therefore, their therapeutic application should be avoided in RMS post puberal patients.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Rhabdomyosarcoma (RMS), one of the most common soft tissue sarcomas of childhood, is very rare in the neonatal period (0.4 –2% of cases). In order to gain a deeper understanding of this disease at such age, pat...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Case report Source Type: research
Authors: von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM, Keedy V, Kim E, Koon H, Mayerson J, McCarter M, McGarry SV, Meyer C, Morris ZS, O'Donnell RJ, Pappo AS, Paz IB, Petersen IA, Pfeifer JD, Riedel RF, Ruo B, Schuetze S, Tap WD, Wayne JD, Bergman MA, Scavone JL Abstract Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with S...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Most patients present with a mass in the head and neck region, urogenital region, or with distal extremity involvement. The authors describe a challenging case of a 6-year-old male patient presenting with mandibular RMS. The clinical/radiographic/tomographic evaluations classified the tumor as an advanced stage (stage IV), with a mass of 6.0 cm involving the left side of the mandible and parotid region. The biopsy revealed round, spindled, and pleomorphic cells with hyperchromatic nuclei and rare larger rhabdomyoblasts with eosinop...
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Brief Clinical Studies Source Type: research
ConclusionThoracic RMS is a rare tumor entity. Completeness of tumor resection significantly improved survival of the patients.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Case records of 28 patients of HNSTS who underwent surgery at the Regional Cancer Centre (RCC), Trivandrum (India) between 2002 and 2012 were analysed retrospectively for demographic profile, clinical features, treatment given, recurrence pattern and outcome. The median age of patients was 37  years (range, 3–79) with male:female ratio of 3:2. Majority of patients presented with painless lump in the neck as the most common subsite affected followed by scalp and face. One patient had nodal disease, whil...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
More News: Anesthesia | Anesthesiology | Brachytherapy | Chemotherapy | Children | CT Scan | External Beam Therapy | MRI Scan | PET Scan | Rhabdomyosarcoma | Sarcomas | Skin | Soft Tissue Sarcoma