Underweight: another risk factor for cardiovascular disease?A cross-sectional 2013 Behavioral Risk Factor Surveillance System (BRFSS) study of 491,773 individuals in the USA

The objective of this study is to investigate whether underweight could be an independent risk factor for CVD in a population-based cross-sectional study. Cross-sectional data of 2013 Behavioral Risk Factor Surveillance System (BRFSS) database encompassing 491,773 US adult subjects were used to assess risk for CVD. Primary outcomes were the incidence and relative risks (RRs) of CVD including stroke, heart attack/myocardial infarction, or coronary artery disease according to BMI category. All analyses used weighted sampling probabilities of data source. The underweight population had a 19.7% greater risk of CVD than did the normal-weight, and the overweight and obese population had a 50% and 96% increased risk, respectively. When adjusted with covariates, the relative risk for CVD elevated in underweight population (adjusted RR 1.34 [95% confidence interval (CI) 1.335–1.348]). Conversely, the adjusted relative risk was significantly attenuated in the obese group (adjusted RR 1.149 [95% CI 1.147–1.151]) and it was even insignificant in the overweight group (adjusted RR 1.00 [95% CI 1.000–1.003]). In subanalysis for each CVD category, being underweight among BMI status was the strongest independent risk factor for stroke (adjusted RR 1.441 [95% CI 1.431–1.450]), heart attack/ myocardial infarction (MI) (adjusted RR 1.23 [95% CI 1.217–1.233]), and angina/coronary artery disease (adjusted RR 1.20 [95% CI 1.189–1.206]). Especially among the population below 40-year ol...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research