Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium

We report the case of a 53‐year‐old male with a history of acute myelogenous leukemia, who suffered the rupturing of a right‐sided pulmonary artery pseudoaneurysm combined with pneumonia. He underwent a right‐sided lower lobectomy. The resected lung tissue demonstrated a mycotic pseudoaneurysm of a pulmonary artery branch together with a filamentous fungal infection. Pseudoaneurysms are caused by the breaching of all layers of a blood vessel wall. The extravasated blood is trapped by the surrounding extravascular tissue or clots. Cladosporium was detected during a polymerase chain reaction‐based analysis followed by DNA sequencing of formalin‐fixed paraffin‐embedded lung tissue samples. Although previous cases of pulmonary artery pseudoaneurysms caused by fungal infections, e.g., Candida or Aspergillus sp., have been reported, to the best of our knowledge this is the first case to involve cladosporiosis.

Source: Pathology International - November 1, 2017 Category: Pathology Authors: Keishin Sunagawa, Yoshihito Uchino, Shinichirou Ishimoto, Shigeki Nakamura, Taku Honma, Yoko Nakanishi, Yoshihiro Hatta, Yoshitsugu Miyazaki, Hiroyuki Sakurai, Hiroyuki Hao, Masahiko Sugitani Tags: Case Report Source Type: research