p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury

Conclusions
We provide experimental evidence that p21 is required for sustained liver regeneration and tumour development in chronic liver injury indicating that p21 needs to be tightly regulated in order to balance liver regeneration and cancer risk. Moreover, we identify p21 as a negative prognostic marker in human HCC.

Source: Gut - August 3, 2014 Category: Gastroenterology Authors: Marhenke, S., Buitrago-Molina, L. E., Endig, J., Orlik, J., Schweitzer, N., Klett, S., Longerich, T., Geffers, R., Sanchez Munoz, A., Dorrell, C., Katz, S.-F., Lechel, A., Weng, H., Krech, T., Lehmann, U., Dooley, S., Rudolph, K. L., Manns, M. P., Vogel, Tags: Hepatic cancer Hepatology Source Type: research