Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast: A case report

Rationale: Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression. Patient concerns: Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma. Immunohistochemically, all myoepithelial and squamous differentiation markers showed typical LGASC positive or negative staining pattern. Interestingly, we found that normally aberrant hormone receptors were reactivated in this case. To our knowledge, this is the first report of a hormone receptor-positive LGASC. Apart from this, in the extended resection sample, we found scattered squamous metaplasia and florid adenosquamous proliferation (ASP). Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP. Diagnosis: LGASC with hormone receptors expression. Interventions: The breast-extended local excision and axillary lymph node dissection were performed. Outcomes: The patient was free of local recurrence and distant metastasis 6 months after surgical resection. Lessons: We here...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research