Glibenclamide and Therapeutic Hypothermia Have Comparable Effect on Attenuating Global Cerebral Edema Following Experimental Cardiac Arrest

ConclusionsGBC attenuated cerebral edema following CA/CPR by blocking Sur1 –TRPM4 channels upregulated by CA insult. The effect of GBC was comparable with that of therapeutic hypothermia alone. These results suggest that GBC is an alternative approach for treating CA-evoked cerebral edema.
Source: Neurocritical Care - Category: Neurology Source Type: research