Retinal changes in patients with major depressive disorder - a controlled optical coherence tomography study

Recent studies on the pathophysiology of major depression (MD) indicate that degenerative and inflammatory processes may play a role. This finding is supported by magnetic resonance imaging (MRI)-based meta-analyses that show volume reductions in circumscribed areas of the brain in patients with MD. Using optical coherence tomography (OCT), retinal changes have been demonstrated in neurodegenerative disorders. In light of this inflammatory/degenerative hypothesis, we tested whether patients with MD exhibit retinal alterations that might correlate with the severity and duration of the disease.

Source: Journal of Affective Disorders - November 16, 2017 Category: Neurology Authors: Carlos Sch önfeldt-Lecuona, Arno Schmidt, Thomas Kregel, Jan Kassubek, Jens Dreyhaupt, Roland W. Freudenmann, Bernhard J. Connemann, Elmar H. Pinkhardt, Maximilian Gahr Tags: Research paper Source Type: research