Role of central versus peripheral opioid system in antinociceptive and anti ‐inflammatory effect of botulinum toxin type A in trigeminal region

ConclusionsMorphine acts on pain in trigeminal region both peripherally and centrally, whereas the effect on dural plasma protein extravasation seems to be only centrally mediated. However, the interaction of BT‐A with endogenous opioid system, with consequent inhibition of nociceptive transmission as well as the DNI, occurs primarily centrally. SignificanceBotulinum toxin type A (BT‐A)'s axonal transport and potential transcytosis suggest that its antinociceptive effect might involve diverse neurotransmitters at different sites of trigeminal system. Here we discovered that the reduction in pain and accompanying DNI involves the interaction of BT‐A with central endogenous opioid system (probably at the level of trigeminal nucleus caudalis).
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research