CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients

In conclusion, the CXCL12/CXCR4 pathway contributes in both mice and patients to the enhanced recruitment of CD4+ T in NASH. An increased affinity of CXCL12 to CXCR4 rather than a higher expression of the chemokine or its receptors is involved in this process.

Source: Clinical Science - July 30, 2014 Category: Biomedical Science Authors: H Boujedidi, O Robert, A Bignon, A Cassard-Doulcier, M Renoud, H Gary-Gouy, P Hemon, H Tharinger, S Prévot, F Bachelerie, S Naveau, D Emilie, K Balabanian, G Perlemuter Source Type: research