IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction

1. IL-18 signaling plays a critical role in bone cancer-induced pain.2. IL-18 signaling could induce GluN2B activation through Src kinase during bone cancer pain.3. IL-18-mediated microglia/astrocyte and microglia/neuron interactions in the dorsal horn.

http://www.jpain.org/article/S1526-5900(17)30751-4/fulltext?rss=yes

Source: The Journal of Pain - October 25, 2017 Category: Materials Science Authors: Su Liu, Yue-peng Liu, You Lv, Jun-Li Yao, Dong-mei Yue, Mao-yin Zhang, Dun-yi Qi, Gong-jian Liu Tags: Original Report Source Type: research