Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation.

In this study, we investigated presynaptic changes in APP knockout (KO) mice. We demonstrate that both sucrose-induced neurotransmission and synaptic depletion in response to high frequency stimulation are significantly enhanced in APP KO compared to wild type littermates. In addition, the level of phosphorylated forms of synapsins, but not total synapsins, is elevated in the KO mice. Furthermore, we show that the inhibition of L-type calcium channels normalizes phosphorylated synapsins and slows down the high frequency induced synaptic depletion in APP KO mice. These results suggest a new mechanism by which APP regulates synaptic vesicle dynamics through synapsin-dependent phosphorylation. PMID: 29052089 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29052089?dopt=Abstract

Source: Neurochemical Research - October 19, 2017 Category: Neuroscience Authors: Liu A, Zhang Y, Han L, He G, Xie W, Zhou Z, Jia Z Tags: Neurochem Res Source Type: research