Effects of long ‐term low oxygen tension in human chondrosarcoma cells

In conclusion, low oxygen condition causes changes in the cellular amounts of several proteins. Long‐term low oxygen tension increased a number of gene expressions, while elevated ACAN and COL2A1 expressions did not reveal changes at secretion levels during the 4‐week exposure period. Still, the low oxygen tension‐induced trend of the expression of ACAN and COL2A1 was consistent and, therefore, we suggest that 5% low oxygen condition could act as a supportive factor for the known chondrogenicity and/or extracellular matrix production enhancing factors, such as bone morphogenetic protein 4 or Rho‐kinase inhibitor Y‐27632.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research