The impact of KIR –HLA genotype on hepatitis B virus clearance in Iranian infected individuals

AbstractKiller cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. The aim of this study is to investigate the possible association ofKIR genes, their knownHLA ligands and compoundKIR –HLA genotypes with hepatitis B virus (HBV) infection. Our study group consisted of 202 Iranian HBV-infected patients (52 spontaneously recovered, 50 asymptomatic carriers, 50 chronic sufferers and 50with liver cirrhosis) and 100 ethnic-matched healthy control subjects.KIR andHLA genotyping was performed by a polymerase chain reaction –sequence-specific primer (PCR–SSP). The frequencies of theKIR2DL5A,KIR2DS1, andKIR3DS1 genes were significantly elevated in recovered individuals when compared with both control and patient groups. Also,KIR2DL5, andKIR3DP1 full were escalated in recovered individuals in comparison with patient groups. In addition,HLA-Bw4 ligand andHLA-A Bw4 were highly frequent in recovered individuals compared with healthy controls. Furthermore, theKIR3DS1 + HLA-Bw4,KIR3DS1 + HLA-Bw4Iso80, andKIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. Interestingly, AA genotype had less frequency and Bx had higher frequency in recovered individuals compared with both healthy control and patient groups. Our findings suggest a...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research