Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway and Aggravates Hepatocellular Damage In Mouse Ischemic Livers

Conclusions: Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and exacerbates hepatocellular injury by inhibiting transcriptional repressor Hes1 and inducing scaffold protein JSAP1 in IR‐triggered liver inflammation. Our findings underscore the crucial role of the Notch‐Hes1 axis as a novel regulator of innate immunity‐mediated inflammation and imply the therapeutic potential for the management of organ IRI in transplant recipients. This article is protected by copyright. All rights reserved.

Source: Hepatology - October 12, 2017 Category: Internal Medicine Authors: Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W. Busuttil, Qi ‐Long Ying, Jerzy W. Kupiec‐Weglinski, Bibo Ke Tags: Liver Injury and Regeneration Source Type: research