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Ultrasound ‑targeted microbubbles combined with a peptide nucleic acid binding nuclear localization signal mediate transfection of exogenous genes by improving cytoplasmic and nuclear import.

In conclusion, UTMD combined with AT‑MCB and a PNA‑binding NLS plasmid significantly improved transfection efficiency by increasing cytoplasmic and nuclear DNA import. This method is a promising strategy for the noninvasive and effective delivery of target genes or drugs for the treatment of cardiovascular diseases. PMID: 28990051 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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An Italian diagnostic imaging company is teaming with a Chicago startup to study whether microbubbles can deliver personalized gene therapy to treat high LDL cholesterol. Microbubble technology, combined with contrast-enhanced ultrasound, has been used diagnostically for years and more recently has inspired research for treatment of disease. Milan-based Bracco Imaging, S.p.A. is working with Steven Feinstein, a professor of medicine at Rush University Medical Center and president of SonoGene, LLC to pursue the treatment possibilities further. A CEUS researcher, Feinstein is also co-president of the  International Cont...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
Abstract Magnetic resonance-guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essential tremor. At a lower energy, MRgFUS can disrupt the blood-brain barrier (BBB) to allow passage of drugs. This focal disruption of the BBB can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the BBB are invasive, as the BBB is relatively impermeable to systemically delivered antineoplastic agents. Multiple healthy and brain tumor animal models have suggested that MRgFUS disrupts the BBB and focally in...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Contrast developer Bracco Diagnostics has received U.S. Food and Drug Administration...Read more on AuntMinnie.comRelated Reading: Bracco targets gene therapy for ultrasound contrast Bracco declines comment on Norris gadolinium lawsuit Bracco Imaging acquires SurgVision Bracco invests in dose monitoring firm Bracco unveils colon insufflator
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Contrast developer Bracco Imaging has launched an initiative aimed at expanding...Read more on AuntMinnie.comRelated Reading: Bracco declines comment on Norris gadolinium lawsuit Bracco Imaging acquires SurgVision Bracco invests in dose monitoring firm Bracco unveils colon insufflator ESR partners with Bracco on fellowships
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Bracco Imaging has launched a new effort at its Switzerland-based R&D center to evaluate gas-filled microbubbles, usually used for diagnostic imaging, as a delivery vehicle for personalized gene therapies to treat chronic dysfunctional diseases linked to lipid metabolism. The research project is part of a deal that Bracco signed with startup SonoGene, which is developing platforms for the therapeutic delivery of genes and drugs using ultrasound-triggered microbubble delivery systems. Get the full story at our sister site, Drug Delivery Business News. The post Bracco Imaging explores using microbubbles to deliver perso...
Source: Mass Device - Category: Medical Devices Authors: Tags: Diagnostics Drug-Device Combinations Imaging Pharmaceuticals Research & Development Bracco Diagnostics Source Type: news
Abstract Various gene delivery systems have been widely studied for the acute spinal cord injury (SCI) treatment. In the present study, a novel type of brain-derived neurotrophic factor (BDNF)-loaded cationic nanobubbles (CNBs) conjugated with MAP-2 antibody (mAbMAP-2/BDNF/CNBs) was prepared to provide low-intensity focused ultrasound (LIFU)-targeted gene therapy. In vitro experiments, the ultrasound-targeted tranfection to BDNF overexpressioin in neurons and efficiently inhibition neuronal apoptosis have been demonstrated, and the elaborately designed mAbMAP-2/BDNF/CNBs can specifically target to the neurons. Fur...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
We reported a surge in the use of augmented reality in healthcare at the end of 2016, with the trend continuing in 2017. Notably, Microsoft’s HoloLens was successfully used for spinal surgery applications by a surgical navigation company named ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Source Type: blogs
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Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research
ConclusionIntra-arterial delivery of transduced-MSCs is feasible and, after CPA injection, resulted in 78% tumor necrosis (p = 0.006) and less metastasis in a VX2 liver tumor model.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
We examined the changing landscape of surgery for PD to appraise the value of various procedures in the context of advances in our understanding and technology. We assessed the number of articles published on neurosurgical procedures for PD over time as an albeit imprecise surrogate for their usage level. We identified over 8,000 publications associated with PD surgery. Over half the publications were on DBS. The field of DBS for PD showed a rapid rise in articles, but is now in a steady state. Thalamotomy and, to a lesser extent, pallidotomy follow a biphasic publication distribution with peaks approximately 30 years apar...
Source: Movement Disorders - Category: Neurology Authors: Tags: Review Source Type: research
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