Ultrasound ‑targeted microbubbles combined with a peptide nucleic acid binding nuclear localization signal mediate transfection of exogenous genes by improving cytoplasmic and nuclear import.

In conclusion, UTMD combined with AT‑MCB and a PNA‑binding NLS plasmid significantly improved transfection efficiency by increasing cytoplasmic and nuclear DNA import. This method is a promising strategy for the noninvasive and effective delivery of target genes or drugs for the treatment of cardiovascular diseases. PMID: 28990051 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28990051?dopt=Abstract

Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research