Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women: a review.

Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women: a review. Minerva Ginecol. 2017 Oct 09;: Authors: Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R Abstract The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant failure reported in the literature had been related to Hepatits E Virus mainly and had been concentrated in Indian subcontinent and some African areas, whereas the problem seems to be very low or absent in the remaining geographical areas. However, the rate of maternal mortality due to fulminant E hepatitis may vary inside the endemic areas of India and Africa, likely due to the circulation of HEV genotypes with different degree of virulence. The other hepatitis viruses have not been reported to cause a greater risk for fulminant hepatitis in pregnant women respect to non pregnant ones, except Herpes Simplex Virus, that has been associated to some cases of fatal hepatitis in absence of a prompt antiviral th...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research